Habib I.H.I.Rizk M.Mohamed D.Mowaka S.El-Eryan R.T.Microanalytical Chemistry LaboratoryApplied Organic Chemistry DepartmentNational Research CentreDokkiGiza12622Egypt; Analytical Chemistry DepartmentFaculty of PharmacyHelwan UniversityCairo11745Egypt; Pharmaceutical Analytical Chemistry DepartmentFaculty of PharmacyOctober University for Modern Sciences and Arts6 October City11787Egypt; Analytical Chemistry DepartmentFaculty of PharmacyBritish University in EgyptEl-Sherouk City11837Egypt2020-01-092020-01-09201614523981https://doi.org/10.20964/2016.06.64PubMed ID :https://t.ly/KXwxpScopusA new square wave voltammetric (SWV) method has been developed and validated for the determination of Rasagiline mesylate in bulk, dosage form and human plasma due to a cathodic behaviour of its acetylene group at Hanging Mercury Drop Electrode (HMDE). Many facts such as different supporting electrolytes, scan rate, pulse amplitude, accumulation time and accumulation potential were studied. A good linearity was obtained over a concentration range of (2.8 x10-8 to1.4 x10-7mol L-1) with 99.78% as mean recovery and 1.09%, as the relative standard deviation and limits of detection and quantification were found to be (2.7 x10-9 and 9.24 x1 0-9mol L-1), respectively. The accuracy and precision of the method were within acceptable limits. The method was applied for determining the active ingredients in its tablets with % recoveries � relative standard deviation of 95.46 � 3.7 6 and in spiked human plasma with 94.3 � 2.8 9%, respectively. � 2016 The Authors.EnglishOctober University for Modern Sciences and Artsجامعة أكتوبر للعلوم الحديثة والآدابUniversity of Modern Sciences and ArtsMSA UniversityAcetylene groupHanging mercury drop electrodeRasagiline mesylateSquare wave voltammetryArticlehttps://doi.org/10.20964/2016.06.64PubMed ID :