Egbuna, ChukwuebukaParmar, Vijaykumar K.Jeevanandam, JaisonEzzat, Shahira MPatrick-Iwuanyanwu, Kingsley CAdetunji, Charles OluwaseunKhan, JohraOnyeike, Eugene NUche, Chukwuemelie ZedechAkram, MuhammadIbrahim, Mervat SEl Mahdy, Nihal MAwuchi, Chinaza GodswillSaravanan, KaliyaperumalTijjani, HabibuOdoh, Uchenna EstellaMessaoudi, MohammedIfemeje, Jonathan COlisah, Michael CEzeofor, Nebechi JaneChikwendu, Chukwudi JudeIbeabuchi, Chinwe Gloria2021-08-022021-08-027/30/2021https://doi.org/10.1155/2021/9954443https://qrgo.page.link/s5pvMNanoparticles are of great importance in development and research because of their application in industries and biomedicine. )e development of nanoparticles requires proper knowledge of their fabrication, interaction, release, distribution, target, compatibility, and functions. )is review presents a comprehensive update on nanoparticles’ toxic effects, the factors underlying their toxicity, and the mechanisms by which toxicity is induced. Recent studies have found that nanoparticles may cause serious health effects when exposed to the body through ingestion, inhalation, and skin contact without caution. )e extent to which toxicity is induced depends on some properties, including the nature and size of the nanoparticle, the surface area, shape, aspect ratio, surface coating, crystallinity, dissolution, and agglomeration. In all, the general mechanisms by which it causes toxicity lie on its capability to initiate the formation of reactive species, cytotoxicity, genotoxicity, and neurotoxicity, among others.en-USimmunotoxicityreproductive toxicitygenotox- icityneurotoxicityNanoparticlesToxicityBiomedicalNanotoxicologyArticlehttps://doi.org/10.1155/2021/9954443