Mohamed A.Aref A.Talima S.A Elshimy R.Gerges S.Meghed M.Zahran F.El-Adawy E.Abd-Elsalam S.Department of Biochemistry and Molecular BiologyNational Hepatology and Tropical Medicine Research instituteNasr CityCairoEgypt; Faculty of BiotechnologyOctober University for Modern Sciences and Arts (MSA)Giza CityGizaEgypt; Department of Clinical OncologyKasr Al-Ainy Center of Clinical Oncology and Nuclear Medicine (NEMROCK)Kasr Al-Ainy School of MedicineCairo UniversityGiza CityGizaEgypt; Department of Clinical PathologyNational Cancer InstituteCairo UniversityCairo GovernorateMansoura CityEgypt; Department of SurgeryNational Hepatology and Tropical Medicine Research instituteNasr CityCairoEgypt; Department of Internal MedicineFaculty of Medicine (Girls)Al-Azhar UniversityNasr CityCairoEgypt; Department of Internal Medicine and EndocrinologyFaculty of MedicineMansoura UniversityElgomhouria StMansoura CityEgypt; Department of Tropical MedicineFaculty of Medicine Tanta Universityl-GaishTanta Qism 2TantaGharbia GovernorateEgypt2020-01-092020-01-0920190019509Xhttps://doi.org/10.4103/ijc.IJC_299_18PubMed ID 31062731https://t.ly/zNMGGScopusBACKGROUND AND AIMS: Pancreatic cancer (PC) is the fourth most common cause of death from cancer in Egypt. Few studies have been conducted to assess the relationship between vitamin D serum level and vitamin D receptor (VDR) polymorphisms with the survival of PC patients. This is the first study in Egypt to investigate the association of the status of vitamin D serum level and genotypic distribution of single nucleotide polymorphisms (SNP) Fok1 with the risk of developing PC and whether they could detect survival or not. PATIENTS AND METHODS: The study included a total of 47 PC cases that were histopathologically proven to have PC, and 37 controls that were attending at the same time for investigation but proved that they were all PC free. Pre-diagnostic concentrations of vitamin D and VDR polymorphism Fok1 were assessed from all participants in the study. RESULTS: There was a 1.5-fold increase in the serum level of vitamin D in PC patients when compared to non-PC subjects. Regarding VDR Fok1, polymorphism distribution in PC was CC (Wild Type) 26 (55.3%), CT 16 (34%), and TT 5 patients (10.7%). For the control group, CC was found in 24 (64.8%), CT in 12 (32.4%), and TT genotype was found only in one individual 1 (2.8%) with no statistically significant difference between the two studied groups (P 0.72). CONCLUSION: Low serum vitamin D or VDR-SNP is not a risk factor for PC in Egyptian patients. Recommendations to increase vitamin D concentrations in healthy persons for the prevention of cancer and improving overall survival should be carefully considered. 2019 Indian Journal of Cancer | Published by Wolters Kluwer -Medknow.EnglishPancreatic cancerrisksurvivalVitamin DVitamin D receptor polymorphismalanine aminotransferasealkaline phosphatasealpha fetoproteinaspartate aminotransferasebilirubincholesterolgamma glutamyltransferasetriacylglycerolvitamin Dvitamin D receptorcalcitriol receptorVDR protein, humanvitamin DadultArticlebody massbody temperaturecancer stagingcancer survivalclinical articlecontrolled studyDNA extractionfemalegenotypehistopathologyhumanmalemiddle agedoverall survivalpancreas cancerprothrombin timerisk factorsingle nucleotide polymorphismbloodgenetic association studygenetic predispositiongeneticspancreas tumorpathologyrisk factorsingle nucleotide polymorphismAdultFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedPancreatic NeoplasmsPolymorphism, Single NucleotideReceptors, CalcitriolRisk FactorsVitamin DArticlehttps://doi.org/10.4103/ijc.IJC_299_18PubMed ID 31062731