Browsing by Author "Yassin, Ghada E."

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Box-Behnken Experimental Design in Development of Glimepiride Floating Matrix Tablets
(americanscience, 2012) Ramadan, Afaf A; Yassin, Ghada E.
Floating matrix tablets of Glimepiride were developed to enhance its bioavailability by prolonging the gastric residence time in which Glimepiride was chosen as a model drug because of its has incomplete absorption due to its low gastric residence time. Floating matrix tablets were prepared using melt granulation technique. Bees wax was used as a hydrophobic meltable material. Hydroxypropylmethyl cellulose (Hypromellose K4MCR), sodium bicarbonate (sodium bicarb.) and ethyl cellulose (EC) were used as matrixing agent, gas generating agent and floating enhancer, respectively. Tablets were evaluated for physical characteristics such as weight, thickness, hardness, % friability and drug content. Tablets also were subjected to in vitro evaluation as buoyancy test (floating lag time), floating duration and drug release profile for 24 hours. A Box – Behnken design was applied to investigate the combined effect of 3 formulation variables including amount of hypromellose (X1), sodium bicarbonate (X2) as well as ethyl cellulose (X3). Fifteen batches were prepared and evaluated. Floating lag time, Flag (Y1), percent of drug released in 5 hours (Y2) and percent of drug released in 12 hours (Y3) were taken as responses. Obtained results of multiple regression analysis indicated that, high level of hypromellose (50 mg), high level of sodium bicarbonate (20 mg) and intermediate level of ethyl cellulose (15 mg) should be used to manufacture the tablet formulations with the desired in vitro floating time and dissolution. In addition; Formulations developed using Box – Behnken design, were fitted to various kinetic models for drug release. Formulation F7 was selected as a promising formulatio
Formulation and Evaluation of Optimized Clotrimazole Emulgel Formulations
(SCIENCEDOMAIN international, 2014) Yassin, Ghada E.
Aims: The aim of the present study was to develop an emulgel formulation of Clotrimazole using carbopol 934 or hydroxyl propyl methyl cellulose 2910 as a gelling agent. The influence of the type of gelling agent and the concentration of both the oil phase and the emulsifying agent on the release of the drug and its microbial activity were investigated using 23 factorial designs. In addition, rheological properties were also evaluated. Methodology: Within the major group of semisolid preparations, emulgel has emerged as a promising drug delivery system for the delivery of hydrophobic drugs. Different emulgel formulations were optimized using a 23 factorial design considering three independent factors at two levels; gelling agent (carbopol 934 and hydroxyl propyl methyl cellulose, liquid paraffin (2.5% and 5%) and emulsifying agent (1.5 and 2.5%). The amount of drug released (Y1) and the antifungalactivity (Y2) were chosen as two dependent responses. The prepared emulgel were also evaluated for their physical properties, pH, drug content and rheological properties. Results: The prepared emulgel exhibited higher release when compared with canest in cream as a market product. Rheological study revealed that the emulgel exhibited a thixotropic behavior. Candida albicans was used as a model fungus to evaluate the antifungal activity of the prepared formulations achieved using canestin cream as a control. Stability studies revealed no significant differences before and after storage for the selected formula. Conclusion: It was suggested that Clotrimazole emulgel formulation (F6) prepared using HPMC 2910 as gelling agent, emulsifying agent in its high level and liquid paraffin in its low level was the formula of choice since it showed the highest drug release and the highest antifungal activity.