Browsing by Author "Ulber, Roland"

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    Fucoidans as nanoparticles: pharmaceutical and biomedical applications
    (Elsevier, 14/01/2022) Zayed, Ahmed; Haggag, Yusuf; Ezzat, Shahira M; Salem, Mohamed A; Ulber, Roland
    Fucoidans are multifunctional marine sulfated polysaccharides. They have gained much interest in the last few decades, due to promising and diverse biological activities. Additionally, nanobiotechnology is a relatively new scientific field, which has been developed to improve the quality of life, including medicine. Formulation of fucoidans in nanoparticles has taken different forms owing to their polyanionic and reducing nature. They are used in either plain preparations or as a capping agent for various metal nanoparticles or in combination with other cationic polymers as a drug carrier. These applications have resulted in increasing the medical efficiency of fucoidans, opening new era in drug delivery systems for anticancers and antibiotics and helping diagnosis of human diseases as well. The current chapter deals with different aspects regarding technologies used for fucoidans nanoparticles synthesis and utilization of such formulations specifically in the fields of nanomedicine.
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    Molecular Networking Leveraging the Secondary Metabolomes Space of Halophila stipulaceae (Forsk.) Aschers. and Thalassia hemprichii (Ehrenb. ex Solms) Asch. in Tandem with Their Chemosystematics and Antidiabetic Potentials
    (MDPI, 2021-05) Hegazi, Nesrine M; Saad, Hamada H; Marzouk, Mona; Abdel Rahman, Mohamed F; El Bishbishy, Mahitab H; Zayed, Ahmed; Ulber, Roland; Ezzat, Shahira M
    The Red Sea is one of the most biodiverse aquatic ecosystems. Notably, seagrasses possess a crucial ecological significance. Among them are the two taxa Halophila stipulacea (Forsk.) Aschers., and Thalassia hemprichii (Ehrenb. ex Solms) Asch., which were formally ranked together with the genus Enhalus in three separate families. Nevertheless, they have been recently classified as three subfamilies within Hydrocharitaceae. The interest of this study is to explore their metabolic profiles through ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UPLC- HRMS/MS) analysis in synergism with molecular networking and to assess their chemosystematics relationship. A total of 144 metabolites were annotated, encompassing phenolic acids, flavonoids, terpenoids, and lipids. Furthermore, three new phenolic acids; methoxy benzoic acid-O-sulphate (16), O-caffeoyl-O-hydroxyl dimethoxy benzoyl tartaric acid (26), dimethoxy benzoic acid-O-sulphate (30), a new flavanone glycoside; hexahydroxy-monomethoxy flavanone-O-glucoside (28), and a new steviol glycoside; rebaudioside-O-acetate (96) were tentatively described. Additionally, the evaluation of the antidiabetic potential of both taxa displayed an inherited higher activity of H. stipulaceae in alleviating the oxidative stress and dyslipidemia associated with diabetes. Hence, the current research significantly suggested Halophila, Thalassia, and Enhalus categorization in three different taxonomic ranks based on their intergeneric and interspecific relationship among them and supported the consideration of seagrasses in natural antidiabetic studies.