Browsing by Author "Sherif S.M."

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    The reaction of cyclohexan-1,3-dione with cyanomethylenes: Synthesis of thiophenes and their fused derivatives with antifungal activities
    (2009) Mohareb R.M.; Sherif S.M.; Moustafa H.E.-D.; Department of Organic Chemistry; Faculty of Pharmacy; October University for Modern Sciences and Arts (MSA); El-Wahaat Road; October; A. R.; Egypt; Department of Chemistry; Faculty of Science; Cairo University; Giza; A. R.; Egypt
    2-Amino-7-oxotetrahydrobenzo[b]thiophenes 3a,b were prepared according to the Gewald procedure. Their reactivity toward a variety of chemical reagents was studied to give annulated heterocycles with potential bio-responses.
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    The reaction of β-amino-α,γ-dicyanocrotononitrile with acetophenone: Synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities
    (2008) Mohareb R.M.; El-Sharkawy K.A.; Sherif S.M.; Department of Chemistry; Faculty of Science; Cairo University; Giza; Egypt; Department of Organic Chemistry; Faculty of Pharmacy; October University for Modern Sciences and Arts (MSA); October; Egypt
    Condensation of ?-amino-?,?-dicyanocrotononitrile (1) with acetophenone gave 2-amino-4-phenylpenta-1,3-diene-1,1,3-tricarbonitrile (2). The latter product was used in a series of heterocyclization reactions with different reagents such as diazonium salts, hydrazines, hydroxylamines and elemental sulfur to give pyridazine, pyrazole, isoxazole and thiophene derivatives, respectively. On the other hand, it gave pyridine derivatives with aromatic aldehydes folowed by reaction with cyanomethylene reagents. The MIC values for the newly synthesized product were measured against E. coli, B. cereus, B. subtilis and C. albicans.