Browsing by Author "Sharifi-Rad, Javad"

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Artemisia spp.: An Update on Its Chemical Composition, Pharmacological and Toxicological Profiles
(Hindawi Publishing Corporation, 2022-09) Sharifi-Rad, Javad; Herrera-Bravo, Jesús; Semwal, Prabhakar; Painuli, Sakshi; Badoni, Himani; Ezzat, Shahira M; Farid, Mai M; Merghany, Rana M; Aborehab, Nora M; Salem, Mohamed A; Sen, Surjit; Acharya, Krishnendu; Lapava, Natallia; Martorell, Miquel; Tynybekov, Bekzat; Calina, Daniela; Cho, William C
Artemisia plants are traditional and ethnopharmacologically used to treat several diseases and in addition in food, spices, and beverages. The genus is widely distributed in all continents except the Antarctica, and traditional medicine has been used as antimalarial, antioxidant, anticancer, antinociceptive, anti-inflammatory, and antiviral agents. This review is aimed at systematizing scientific data on the geographical distribution, chemical composition, and pharmacological and toxicological profiles of the Artemisia genus. Data from the literature on Artemisia plants were taken using electronic databases such as PubMed/MEDLINE, Scopus, and Web of Science. Selected papers for this updated study included data about phytochemicals, preclinical pharmacological experimental studies with molecular mechanisms included, clinical studies, and toxicological and safety data. In addition, ancient texts and books were consulted. The essential oils and phytochemicals of the Artemisia genus have reported important biological activities, among them the artemisinin, a sesquiterpene lactone, with antimalarial activity. Artemisia absinthium L. is one of the most famous Artemisia spp. due to its use in the production of the absinthe drink which is restricted in most countries because of neurotoxicity. The analyzed studies confirmed that Artemisia plants have many traditional and pharmacological applications. However, scientific data are limited to clinical and toxicological research. Therefore, further research is needed on these aspects to understand the full therapeutic potential and molecular pharmacological mechanisms of this medicinal species.
Hesperetin’s health potential: moving from preclinical to clinical evidence and bioavailability issues, to upcoming strategies to overcome current limitations
(Taylor and Francis, 2021-01) Salehia, Bahare; Cruz-Martinsb, Natalia; oButnariue, Monica; Sarace, Ioan; Bagiu, Iulia-Cristina; Ezzat, Shahira M; Wangi, Jinfan; Koayi, Aaron; Sheridani, Helen; Adetunjij, Charles Oluwaseun; Semwalk, Prabhakar; Schoebitzm, Mauricio; Martorelln, Miquel; Sharifi-Rad, Javad
Flavonoids are common in the plant kingdom and many of them have shown a wide spectrum of bioactive properties. Hesperetin (Hst), the aglycone form of hesperidin, is a great example, and is the most abundant flavonoid found in Citrus plants. This review aims to provide an overview on the in vitro, in vivo and clinical studies reporting the Hst pharmacological effects and to discuss the bioavailability-related issues. Preclinical studies have shown promising effects on cancer, cardiovascular diseases, carbohydrate dysregulation, bone health, and other pathologies. Clinical studies have supported the Hst promissory effects as cardioprotective and neuroprotective agent. However, further well-designed clinical trials are needed to address the other Hst effects observed in preclinical trials, as well as to a more in-depth understanding of its safety profile.
NMDA Inhibitors: A Potential Contrivance to Assist in Management of Alzheimer’s Disease
(Bentham Science Publishers B.V., 2023-03) Painuli, Sakshi; Semwal, Prabhakar; Zam, Wissam; Taheri, Yasaman; Ezzat, Shahira M; Zuo, Peijun; Li, Liping; Kumar, Dileep; Sharifi-Rad, Javad; Cruz-Martins, Natália
Alzheimer’s disease (AD) is an increasingly common neurodegenerative disease that at- tracts the attention of researchers and medical community in order to develop new, safe and more effective drugs. Currently available drugs could only slow the AD progression and relieve the symptoms, in addition to being linked to moderate-to-severe side effects. N-methyl D-aspartate (NMDA) receptors antagonists were reported to have the ability to block the glutamate-mediated excitotoxic activity being good therapeutic targets for several neurodegenerative diseases, includ- ing AD. Based on data obtained so far, this review provides an overview over the use of NMDA antagonists for AD treatment, starting with a key emphasis on present features and future aspects regarding the use of NMDA antagonists for AD, and lastly a key focus is also given on its use in precision medicine.
NMDA Inhibitors: A Potential Contrivance to Assist in Management of Alzheimer Disease
(Bentham Science Publishers, 2022-04) Painuli, Sakshi; Semwal, Prabhakar; Zam, Wissam; Taheri, Yasaman; Ezzat, Shahira M; Zuo, Peijun; Li, Liping; Kumar, Dileep; Sharifi-Rad, Javad; Cruz- Martins, Natália
Alzheimer disease (AD) is an increasingly common neurodegenerative disease, and therefore researchers and medical community are devoting a key attention in searching new, safer and more effective drugs than the currently available ones. Currently available drugs are not an effective treatment to the disease, they only slow the AD progression and act in symptoms relief, despite being linked to moderate-to-severe side effects. N-methyl D-aspartate (NMDA) receptors antagonists and cholinesterase inhibitors, and combination therapy, are the most often used therapeutic regimens in AD patients. In particular, NMDA receptors have being target of an increasing attention while good therapeutic targets for several neurodegenerative diseases, including AD, due to their ability to block the glutamate-mediated excitotoxic activity. Based on data obtained so far, this review provides an overview on the use of NMDA antagonists for AD treatment, starting with a key emphasis on present features and future aspects on the use of NMDA antagonists for AD, and lastly a key focus is also given on its use for precision medicine.
Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights
(Wiley-VCH Verlag, 2024-04) Ezzat, Shahira M; Merghany, Rana M; Abdel Baki, Passent M; Abdelrahim, Nariman Ali; Osman, Sohaila M; Salem, Mohamed A; Peña-Corona, Sheila I; Cortés, Hernán; Kiyekbayeva, Lashyn; Leyva-Gómez, Gerardo; Sharifi-Rad, Javad; Calina, Daniela
Phenethyl isothiocyanate (PEITC), a compound derived from cruciferous vegetables, has garnered attention for its anticancer properties. This review synthesizes existing research on PEITC, focusing on its mechanisms of action in combatting cancer. PEITC has been found to be effective against various cancer types, such as breast, prostate, lung, colon, and pancreatic cancers. Its anticancer activities are mediated through several mechanisms, including the induction of apoptosis (programmed cell death), inhibition of cell proliferation, suppression of angiogenesis (formation of new blood vessels that feed tumors), and reduction of metastasis (spread of cancer cells to new areas). PEITC targets crucial cellular signaling pathways involved in cancer progression, notably the Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB), Protein Kinase B (Akt), and Mitogen-Activated Protein Kinase (MAPK) pathways. These findings suggest PEITC's potential as a therapeutic agent against cancer. However, further research is necessary to determine the optimal dosage, understand its bioavailability, and assess potential side effects. This will be crucial for developing PEITC-based treatments that are both effective and safe for clinical use in cancer therapy.
The Pharmacological Activities of Crocus sativus L.: A Review Based on the Mechanisms and Therapeutic Opportunities of its Phytoconstituent
(Hindawi, 14/02/2022) Butnariu, Monica; Quispe, Cristina; Herrera-Bravo, Jesús; Sharifi-Rad, Javad; Singh, Laxman; Aborehab, Nora M; Bouyahya, Abdelhakim; Venditti, Alessandro; Sen, Surjit; Acharya, Krishnendu; Bashiry, Moein; Ezzat, Shahira M; Setzer, William N; Martorell, Miquel; Mileski, Ksenija S; Bagiu, Iulia-Cristina; Docea, Anca Oana; Calina, Daniela; Cho, William C
Crocus species are mainly distributed in North Africa, Southern and Central Europe, and Western Asia, used in gardens and parks as ornamental plants, while Crocus sativus L. (saffron) is the only species that is cultivated for edible purpose. The use of saffron is very ancient; besides the use as a spice, saffron has long been known also for its medical and coloring qualities. Due to its distinctive flavor and color, it is used as a spice, which imparts food preservative activity owing to its antimicrobial and antioxidant activity. This updated review discusses the biological properties of Crocus sativus L. and its phytoconstituents, their pharmacological activities, signaling pathways, and molecular targets, therefore highlighting it as a potential herbal medicine. Clinical studies regarding its pharmacologic potential in clinical therapeutics and toxicity studies were also reviewed. For this updated review, a search was performed in the PubMed, Science, and Google Scholar databases using keywords related to Crocus sativus L. and the biological properties of its phytoconstituents. From this search, only the relevant works were selected. The phytochemistry of the most important bioactive compounds in Crocus sativus L. such as crocin, crocetin, picrocrocin, and safranal and also dozens of other compounds was studied and identified by various physicochemical methods. Isolated compounds and various extracts have proven their pharmacological efficacy at the molecular level and signaling pathways both in vitro and in vivo. In addition, toxicity studies and clinical trials were analyzed. The research results highlighted the various pharmacological potentials such as antimicrobial, antioxidant, cytotoxic, cardioprotective, neuroprotective, antidepressant, hypolipidemic, and antihyperglycemic properties and protector of retinal lesions. Due to its antioxidant and antimicrobial properties, saffron has proven effective as a natural food preservative. Starting from the traditional uses for the treatment of several diseases, the bioactive compounds of Crocus sativus L. have proven their effectiveness in modern pharmacological research. However, pharmacological studies are needed in the future to identify new mechanisms of action, pharmacokinetic studies, new pharmaceutical formulations for target transport, and possible interaction with allopathic drugs.
Rosmarinus plants: Key farm concepts towards food applications
(wiley online library, 2020-01) Sharifi-Rad, Javad; Ezzat, Shahira M; El Bishbishy, Mahitab H.; Mnayer, Dima; Sharopov, Farukh; Kılıç, Ceyda S.; Neagu, Monica; Constantin, Carolina; Sharifi-Rad, Mehdi; Atanassova, Maria Maria; Nicola, Silvana; Pignata, Giuseppe; Salehi, Bahare; Fokou, Patrick Valere Tsouh; Martins, Natália
Rosmarinus species are aromatic plants that mainly grow in the Mediterranean region. They are widely used in folk medicine, food, and flavor industries and represent a valuable source of biologically active compounds (e.g., terpenoids, flavonoids, and phenolic acids). The extraction of rosemary essential oil is being done using three main methods: carbon dioxide supercritical extraction, steam distillation, and hydrodistillation. Furthermore, interesting antioxidant, antibacterial, antifungal, antileishmanial, anthelmintic, anticancer, anti-inflammatory, antidepressant, and antiamnesic effects have also been broadly recognized for rosemary plant extracts. Thus the present review summarized data on economically important Rosmarinus off- icinalis species, including isolation, extraction techniques, chemical composition, phar- maceutical, and food applications.
Supercharging metabolic health with Lycium barbarum L.: A review of the therapeutic potential of this functional food for managing metabolic syndrome
(John Wiley and Sons Inc, 2024-01) Sharifi-Rad, Javad; Quetglas-Llabrés, Maria Magdalena; Sureda, Antoni; Mardones, Lorena; Villagran, Marcelo; Gürer, Eda Sönmez; Živković, Jelena; Ezzat, Shahira M; Zayed, Ahmed; Gümü¸sok, Safa; Kılıç, Ceyda Sibel; Fasipe, Babatunde; Laher, Ismail; Martorell, Miquel
Metabolic syndrome (MetS) is a common disorder involving a cluster of metabolic abnormalities, such as abdominal obesity, hypertension, dyslipidemia, insulin resistance, and atherogenic profile. MetS is characterized by an increase in oxidative stress and a chronic proinflammatory state, which are directly related to the development and progression of this pathology. It has been seen how a healthy lifestyle and good dietary practices are key to improving the different metabolic parameters and, therefore, play a fundamental role in reducing the risk of developing diabetes. The present review focuses on the research evidence related to the therapeutic properties of Lycium barbarum L. in MetS gathered in the last years. Several preclinical studies suggest that L. barbarum extracts are a good dietary supplement for the prevention of cardiovascular diseases in people with MetS. This compound has been used for years in traditional Chinese medicine for the treatment of atrophic gastritis, problems related to the lungs, kidneys, and liver, and as a supplement for eye health. In addition, different in vitro and in vivo studies have been carried out that support the properties attributed to metabolites derived from L. barbarum, such as polysaccharides that have been shown diverse biological activities. In conclusion, L. barbarum extracts have multiple benefits to increase general well-being and immune function. However, there are a limited number of studies related to effect of L. barbarum in MetS, but they demonstrated effectiveness in the treatment of obesity, diabetes mellitus type 2, and prevention of diabetes mellitus type 2 complication. © 2024 The Authors. Food Frontiers published by Nanchang University, Northwest University, Jiangsu University, Zhejiang University, Fujian Agriculture and Forestry University and John Wiley & Sons Australia, Ltd.
Urtica dioica-Derived Phytochemicals for Pharmacological and Therapeutic Applications
(Hindawi, 2022-02) Taheri, Yasaman; Quispe, KCristina; Herrera-Bravo, Jesu´s; Sharifi-Rad, Javad; Ezzat, Shahira M; Merghany, Rana M; Shaheen, Shabnum; Azmi, Lubna; Mishra, Abhay Prakash; Sener, Bilge; Kılıç, Mehtap; Sen, Surjit; Acharya, Krishnendu; Nasiri, Azadeh; Cruz-Martins, Nata´lia; Fokou, Patrick Valere Tsouh; Ydyrys, Alibek; Bassygarayev, Zhandos; Das¸an, Sevgi Durna; Alshehri, Mohammed M; Calina, Daniela; Cho, William C
Urtica dioica belongs to the Urticaceae family and is found in many countries around the world. 1is plant contains a broad range of phytochemicals, such as phenolic compounds, sterols, fatty acids, alkaloids, terpenoids, flavonoids, and lignans, that have been widely reported for their excellent pharmacological activities, including antiviral, antimicrobial, antihelmintic, anticancer, nephroprotective, hepatoprotective, cardioprotective, antiarthritis, antidiabetic, antiendometriosis, antioxidant, anti-inflammatory, and antiaging effects. In this regard, this review highlights fresh insight into the medicinal use, chemical composition, pharmacological properties, and safety profile of U. dioica to guide future works to thoroughly estimate their clinical value.