Browsing by Author "Mohamed, Abdelrahman"

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Dual Targeting of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis
(American Chemical Society, 2022) Mohamed, Abdelrahman; Salah, Mohamed; Tahoun, Mariam; Hawner, Manuel; Abdelsamie, Ahmed S; Frotscher, Martin
A novel approach for the dual inhibition of steroid sulfatase (STS) and 17ß-hydroxysteroid dehydrogenase type 1(17ß HSD1) by a single drug was explored, starting from in-house 17ß HSD1 inhibitors via masking their phenolic OH group with a sulfamate ester. The sulfamates were intentionally designed as drugs for the inhibition of STS and, at the same time, prodrugs for 17ß-HSD1 inhibition ("drug-prodrug approach"). The most promising sulfamates 13, 16, 18-20, 22-24, 36, and 37 showed nanomolar IC50 values for STS inhibition in a cellular assay and their corresponding phenols displayed potent 17ß-HSD1 inhibition in cell-free and cellular assays, high selectivity over 17ß-HSD2, reasonable metabolic stability, and low estrogen receptor a affinity. A close relationship was found between the liberation of the phenolic compound by sulfamate hydrolysis and 17ß-HSD1 inactivation. These results showed that the envisaged drug-prodrug concept was successfully implemented. The novel compounds constitute a promising class of therapeutics for the treatment of endometriosis and other estrogen-dependent diseases. © 2022 American Chemical Society.
Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis
(American Chemical Society, 2022-08) Mohamed, Abdelrahman; Salah, Mohamed; Tahoun, Mariam; Hawner, Manuel; Abdelsamie, Ahmed S; Frotscher, Martin
A novel approach for the dual inhibition of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1(17β HSD1) by a single drug was explored, starting from in-house 17β HSD1 inhibitors via masking their phenolic OH group with a sulfamate ester. The sulfamates were intentionally designed as drugs for the inhibition of STS and, at the same time, prodrugs for 17β-HSD1 inhibition (“drug-prodrug approach”). The most promising sulfamates 13, 16, 18–20, 22–24, 36, and 37 showed nanomolar IC50 values for STS inhibition in a cellular assay and their corresponding phenols displayed potent 17β-HSD1 inhibition in cell-free and cellular assays, high selectivity over 17β-HSD2, reasonable metabolic stability, and low estrogen receptor α affinity. A close relationship was found between the liberation of the phenolic compound by sulfamate hydrolysis and 17β-HSD1 inactivation. These results showed that the envisaged drug-prodrug concept was successfully implemented. The novel compounds constitute a promising class of therapeutics for the treatment of endometriosis and other estrogen-dependent diseases.
Impact of Creative Accounting on Shareholders Wealth
(MSA Accounting Graduation Projects - MSA Library, 2022) Kamal, Abdelwahab; Magged, Ahmed; Alaa, Omar; Mohamed, Abdelrahman
This project aims to evaluate and examine the effect of the independent variable creative accounting on the dependent variable stockholders wealth. The sample covers 40 non-financial companies listed in Egypt Stock Exchange (EGX100) during the period 2017 to 2020. In this research modified jones model is going to be used to measure the independent variable which is the creative accounting and the log of shareholders equity is going to be the measure of the dependent variable shareholders wealth. The results found that there is no relationship between creative accounting and shareholders wealth. The research recommends to use more than 40 non-financial companies to investigate more the relationship between creative accounting and shareholders wealth or, using different types of companies like, financial companies as a sample.