Browsing by Author "Moaz, Inas"

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    Associations Between Serum Soluble Toll-like Receptors 4 and 9 and Breast Cancer in Egyptian Patients
    (SAGE Publications Ltd, 2023-09) Moaz, Inas; Fouad, Fayrouz A; Elmasry, Hossam; Tarek, Gehad; Elzoheiry, Aya; Elgamal, Manar; Ibrahim, Randa; Hisham, Yasmin; Safwat, Gehan; Kamel, Mahmoud M; El-Batal, Heba M; Fouda, Merhan
    Background: Toll-like receptors (TLRs) play an important role in regulation of immune cells and are vital in tumorigenesis due to its crucial role in inflammatory microenvironment regulation, as they promote the synthesis and release of inflammatory cytokines and chemokines. Toll-like receptors 4 and TLRs 9 were found to be highly expressed in breast cancer. The aim of this study is to investigate the soluble toll-like receptors 4 and 9 (sTLR4 and sTLR9) as potential biomarkers for diagnosis and prognosis of breast cancer and their association with the clinicopathological parameters of breast cancer. Patients and Method: In this retrospective case-control study, 186 female subjects were recruited and divided into three groups, Group I: 62 healthy control, Group II: 62 subjects diagnosed with non-metastatic breast cancer, and Group III: 62 subjects diagnosed with metastatic breast cancer. Enzyme-linked immunosorbent assay (ELISA) technique was used to quantify the levels of sTLR4 and sTLR9 in serum. Results: Both non-metastatic and metastatic groups showed significant higher levels of both serum sTLR4 and sTLR9 expression compared to healthy controls. Only sTLR9 was significantly increased among metastatic patients compared to non-metastatic group. Serum levels of sTLR9 and sTLR4 were still significantly associated with breast cancer in a multiple logistic regression model (P = <.001). ROC curves showed that both sTLR4 and sTLR9 can be a significant parameter to discriminate between normal females and breast cancer patients. Conclusion: Soluble toll-like receptors 4 and sTLR9 are over-expressed in patients with metastatic and non-metastatic BC than in benign cases. The expression levels of sTLR4 and TLR9 have clinical interest as indicators of tumor aggressiveness suggested to be prognostic biomarkers. Toll-like receptors may represent therapeutic targets in breast cancer.
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    Evaluation And Re-Evaluation Of Post-Mastectomy Pain Syndrome By Breast Cancer Edge Task Force Outcomes: Clinical Measures Of Pain After Pain Management Protocol Of Physiotherapy
    (Wolters Kluwer Medknow Publications, 2022-07) Ahmed, Omnia Saeed Mahmoud; Youssef, Lamiaa; Moaz, Inas; Aboali, Safy Eldin Mahmoud
    Introduction In many societies, the prevalence of chronic pain following breast cancer therapy ranges from 25% to 60%. Patients undergoing surgery may be more likely to experience chronic, often neuropathic pain after surgery due to the mechanism of post- mastectomy pain syndrome (PMPS), pain sensitivity, and/or central sensitization. PMPS is evaluated and reevaluated using the Evaluation Database to Guide Effectiveness (EDGE) task force outcome measurements. Methods. 10 female patients from a Baheya Center for Early Detection and Treatment of Breast Cancer facility were diagnosed with PMPS following mastectomy. The purpose of this study is to evaluate PMPS in patients who have had mastectomy before and after a pain treatment protocol of six physiotherapy sessions, followed by follow-up. Results. A total of 10 women answered the questionnaires and showed changes in patient feeling is heavy sensation according to the McGill pain Questionnaire-short form (MPQ-S.F) results (p-value = 0.02), and in patient's activities of daily living (ADLs) disability is recreation according to the Pain disability index (PDI) results (p-value = 0.02), and in neuropathic signs and symptoms is tingling sensation according to the Neuropathic pain scale (NPS) results (p-value = 0.02), and in patient's physical well-being is a feeling of nausea (p-value = 0.03) and spending time in bed (p-value = 0.04). Conclusions. According to this study, there have been initial improvements in the feeling of heaviness, neuropathic symptoms like tingling and discomfort in the hands and feet, physical wellbeing, and facial expressions. Trial Registration. NCT05458154