Browsing by Author "Mahfouz R.Z."

Now showing 1 - 4 of 4

Epidemiology of dermatophyte infections among school children in Menoufia Governorate, Egypt
(Blackwell Publishing Ltd, 2018) Farag A.G.A.; Hammam M.A.; Ibrahem R.A.; Mahfouz R.Z.; Elnaidany N.F.; Qutubuddin M.; Tolba R.R.E.; Dermatology; Adrology and STDs Department; Faculty of Medicine; Menoufia University; Shebin El-Kom; Egypt; Department of Public Health and Community Medicine; Faculty of Medicine; Menoufia University; Shebin El-Kom; Egypt; Cleveland Clinic; Lerner College of Medicine; Case Western Reserve University; Cleveland; OH; United States; Clinical Pathology; Faculty of Medicine; Menoufia University; Shebin El-Kom; Egypt; Clinical Pharmacy; Faculty of Pharmacy; MSA University; October City; Egypt; Independent Researcher; Cleveland; OH; United States
Most superficial mycotic infections of human skin are due to dermatophytes. Children are frequently affected due to different predisposing factors, particularly overcrowding in classrooms. This study aimed to estimate the prevalence of dermatophytes infections and their related risk factors among school children in Menoufia Governorate, Egypt. Six public primary and preparatory schools were randomly selected and their pupils (n=3464) were asked to complete a predesigned questionnaire covering both personal data and suspected risk factors for superficial dermatophyte infections. The children were also examined for dermatological diseases. Any suspected lesions were biopsied for mycological examination. The prevalence of clinically suspected dermatophytes infections was 1.41%, whereas the prevalence of culture confirmed cases was 0.98%. The most common clinical type was tinea capitis with a prevalence of 1.01%. Microsporum canis was the only isolated organism from the suspicious lesions with a 69.4% positivity rate. A higher prevalence was observed among boys, low socio-economic pupils and those with a family history of dermatophyte infections. Pet contact and sharing towels and caps among pupils were significant risk factors. Dermatophyte infection is still prevalent among basic school pupils. Fortunately, it is related to preventable risk factors. We recommend regular screening and use of educational health programmes for kids to control it. 2018 Blackwell Verlag GmbH
IL-8 mRNA and serum levels in vitiligo patients: A case control study
(Oxford University Press, 2017) Farag A.G.; Marae A.H.; Habib M.S.E.; Mahfouz R.Z.; Elnaidany N.F.; Youssef S.I.; El-Feky S.M.; Department of Dermatology; Andrology and STDs; Faculty of Medicine; Menoufia University; Al Minufiyah; Egypt; Department of Medical Biochemistry; Faculty of Medicine; Menoufia University; Al Minufiyah; Egypt; Department of Clinical Pathology; Menoufia University; Shebin Elkom; Egypt; Cleveland Clinic; Lerner College of Medicine (CCLCM); CWR University; Cleveland; OH; United States; Department of Clinical Pharmacy; Faculty of Pharmacy-MSA University; October City; Egypt; Department of Medical Microbiology and Immunology; October 6 University; Egypt; Department of Dermatology; Ministry of Health; Egypt
Introduction: Many theories are suggested to explain aetiology of vitiligo, such as autoimmune, genetic and biochemical. Interleukin-8 (IL-8) is a pro-inflammatory chemokine which is evaluated in the pathogenesis of some skin diseases, like psoriasis, however, in vitiligo, few studies were reported regarding this issue. Aim: The aim of the present study was to investigate serum level of IL-8 and IL-8 mRNA in patients with different types of vitiligo to validate its role in aetiopathogenesis of vitiligo. Materials and Methods: This case-control study was conducted on 39 vitiligo patients and 15 age and gender matched healthy controls. The participants were selected from Dermatology Outpatient Clinic, Menoufia University Hospitals from October, 2014 to October, 2015. They were subjected to clinical history, examination and full general examination. Detailed dermatological examination including VASI score was applied. IL-8 serum level was measured by ELISA and IL-8 mRNA was quantitated by Real Time -PCR. The statistical analysis was done using SPSS, version 20.0. Mann Whitney U test was used to compare two quantitative not normally distributed. Chi-square test (?2) was used to study association between two qualitative variables. Spearman correlation test was applied to assess correlation between two continuous quantitative variables. A p?0.05 was considered significant. Results: IL-8 serum level and mRNA concentration mean values were significantly elevated in vitiligo patients (26.25�43.28 pg/ mL and 8.48�11.92 ng/mL) than controls (0.57�0.50 pg/mL and 0.60�0.32 ng/mL) (p=0.002, for both), and they showed significant positive correlation with each other (r=0.622; p?0.001). Moreover, both of them revealed significant high values in localized vitiligo (62.20�74.39 pg/mL and 12.42�13.85 ng/mL) than generalized (18.39�29.49 pg/mL and 7.61�11.52 ng/mL) (p?0.000 and p=0.004), respectively. Conclusion: Serum IL-8 chemokine and its mRNA increased significantly in vitiligo patients indicating that it may have a dynamic role in vitiligo development and participate in its pathogenesis. � 2017, Journal of Clinical and Diagnostic Research. All rights reserved.
Mean platelet volume: An immanent predictor of subclinical atherosclerosis in psoriatic patients compared with interleukin-1? and interleukin-6
(Lippincott Williams and Wilkins, 2018) Farag A.G.A.; Zytoon A.A.; Habib M.S.; Elnaidany N.F.; Ibrahem R.A.L.; Salman S.; Mahfouz R.Z.; Department of Dermatology; Andrology and STDs; Faculty of Medicine; Menoufia University; Shebin El-Kom; Menoufia Governorate; 23511; Egypt; Department of Radiology; Faculty of Medicine; Egypt; Department of Medical Biochemistry; Faculty of Medicine; Egypt; Public Health and Community Medicine; Faculty of Medicine; Egypt; Department of Clinical Pathology; Menoufia University; Shebin El-Kom; Menoufia Governorate; Egypt; Department of Clinical Pharmacy; Faculty of Pharmacy; Modern Sciences and Arts University; 6th of October City; Giza Governorate; Egypt; Hematology and Oncology Research; Cleveland Clinic Lerner College of Medicine (CCLCM); Case Western University; Cleveland; OH; United States
Background Mean platelet volume (MPV), may help to determine atherosclerosis threat. Cardiovascular disease is one of the common causes of morbidity and mortality in patients having psoriasis. Objective To examine MPV as a biomarker for subclinical atherosclerosis in psoriasis patients, compared with interleukin (IL)-1?, IL-6, and carotid intima media thickness (CIMT). Patients and methods Psoriatic patients (n=70) and age-matched and sex-matched healthy controls (n=60) were enrolled. Psoriasis Area and Severity Index score was used to assess psoriasis severity. For all enrolled participants; evaluation of MPV, IL-1?, and IL-6 serum levels, and measuring of CIMT were done. Results The mean values of MPV, IL-1, IL-6, and CIMT, all were significantly elevated in psoriatic patients than controls (P<0.05 for all). They were significantly correlated with each other (P<0.001), and with severity of psoriasis. Receiver operating characteristic curve analysis showed the possible validity of MPV for detection of subclinical atherosclerosis in psoriatic patients (sensitivity=90.9%, specificity=61.5%, accuracy=80%, area under the curve=0.82, P<0.001, 95% confidence interval=0.71-92) with 8.95 fl/ml as a cutoff value. Conclusion MPV is a good sensitive test for early prediction of atherosclerosis in psoriatic patients. We recommend a follow-up large scale study on psoriasis to examine the use of antiplatelets. � 2018 Egyptian Women's Dermatologic Society.
Tramadol (opioid) abuse is associated with a dose- and time-dependent poor sperm quality and hyperprolactinaemia in young men
(Blackwell Publishing Ltd, 2018) Farag A.G.A.; Basha M.A.; Amin S.A.; Elnaidany N.F.; Elhelbawy N.G.; Mostafa M.M.T.; Khodier S.A.; Ibrahem R.A.; Mahfouz R.Z.; Dermatology; Andrology and STDs; Menoufia University; Shebin El Kom; Egypt; Forensic Medicine & Clinical Toxicology; Menoufia University; Shebin El Kom; Egypt; Faculty of Pharmacy; Clinical Pharmacy; MSA University; 6 October City; Egypt; Faculty of Medicine; Medical Biochemistry; Menoufia University; Shebin El Kom; Egypt; Faculty of Medicine; Clinical Pathology; Menoufia University; Shebin El Kom; Egypt; Faculty of Medicine; Public Health and Community Medicine; Menoufia University; Shebin El Kom; Egypt; Cleveland Clinic Lerner College of Medicine; Case Western Reserve University; Cleveland; OH; United States
Tramadol, one of the most commonly abused drugs in Middle East, impacts spermatogenesis and disturbs reproductive hormones in animal studies. We aimed to investigate tramadol impact on sperm quality and on levels of testosterone, prolactin and gonadotropins, in tramadol abusers (n=30) to age-matched control (n=30). Abusers had significantly low percentages of sperm motility, normal forms and vitality compared with control (95% CI ?40.7 to ?19.3, ?13.5 to ?9.3 and ?31.9 to ?9.7 respectively). Hypoandrogenism (95% CI ?4.5 to ?2.8), hyperprolactinaemia (CI (95%) 4.9 to 9.4) and hypergonadotropinaemia (95% CI 2.9 to 7.2 for FSH and 2.0 to 7.8 for LH) were observed in tramadol abusers vs controls. Smokers (26 of 30), concurrently abusing other drugs (11 of 30) and asymptomatic leucocytospermic (15 of 30) patients subgroups significantly abused tramadol beyond 3years (p=.02, <.001, =.03 respectively) and in excess >450mg/day (p=.02, =.01, =.005 respectively). Progressive motility (a+b%) was significantly low in young men <25years old (p=.03) subgroup. Tramadol abuse is associated with poor sperm quality, hyperprolactinaemia and hypergonadotropic hypogonadism. We recommend semen analysis for tramadol long-intakes, question sperm donors and follow-up studies to prevent and reverse tramadol-induced testicular damage. � 2018 Blackwell Verlag GmbH