Browsing by Author "Lecerf, Laure"

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    FGFR3 and TP53 Gene Mutations Define Two Distinct Pathways in Urothelial Cell Carcinoma of the Bladder
    (American Association for Cancer Research, 12/01/2003) Bakkar, Ashraf A; Wallerand, Herve; Radvanyi, François; Lahaye, Jean-Baptiste; Pissard, Serge; Lecerf, Laure; Kouyoumdjian, Claude; Abbou, Claude C; Jaurand, Marie-Claude; Pairon, Jean-Claude; Chopin, Dominique K; Diez de Medina, Sixtina Gil
    FGFR3 and TP53 mutations are frequent in superficial papillary and invasive disease, respectively. We used denaturing high-performance liq- uid chromatography and sequencing to screen for FGFR3 and TP53 mutations in 81 newly diagnosed urothelial cell carcinomas. Tumors were classified as follows: 31 pTa, 1 carcinoma in situ, 30 pT1, and 19 pT2-T4. Tumor grades were as follows: 10 G1, 29 G2, and 42 G3. FGFR3 muta- tions were associated with low-stage (P < 0.0001), low-grade (P < 0.008) tumors, whereas TP53 mutations were associated with high-stage (P < 0.003), high-grade (P < 0.02) tumors. Mutations in these two genes were almost mutually exclusive. Our results suggest that FGFR3 and TP53 mutations define separate pathways at initial diagnosis of urothelial cell carcinoma.