Browsing by Author "Hamed A.N.E."

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    Metabolomic profiling and biological investigation of Tabebuia Aurea (Silva Manso) leaves, family Bignoniaceae
    (Taylor and Francis Ltd., 2019) Mahmoud B.K.; Hamed A.N.E.; Samy M.N.; Abdelmohsen U.R.; Attia E.Z.; Fawzy M.A.; Refaey R.H.; Salem M.A.; Pimentel-Elardo S.M.; Nodwell J.R.; Desoukey S.Y.; Kamel M.S.; Department of Pharmacognosy; Faculty of Pharmacy; Minia University; Minia; Egypt; Department of Pharmacognosy; Faculty of Pharmacy; Deraya University; New Minia City; Egypt; Departmentof Biochemistry; Faculty of Pharmacy; Minia University; Minia; Egypt; Department of Pharmaceutical Chemistry; Faculty of Pharmacy; October University of Modern Sciences and Arts (MSA); Giza; Egypt; Department of Biochemistry; University of Toronto; Toronto; ON; Canada
    Both ethyl acetate and aqueous fractions of Tabebuia aurea leaves exhibited noteworthy antioxidant and nephroprotective activities against carbon tetrachloride (CCl4)-induced nephrotoxicity in rats, as evidenced by the remarkable improvements of renal serum biomarkers and histopathological features. Additionally, the ethyl acetate fraction displayed a prominent in vitro antitrypanosomal activity against Trypanosoma brucei; consequently, the leaves were subjected to LC-HR-ESI-MS metabolomic profiling to discover the constituents that possibly underlie their bioactivities. Therefore, ten metabolites were characterized, mostly dominated by flavonoids. Interestingly, two identified constituents viz., 3,9,12,15-octadecatetraenoic acid (9) and 9,11,13-octadecatrienoic acid (10) are reported firstly herein from the genus Tabebuia. Furthermore, among the dereplicated constituents, rutin (5) and kaempferol 3-O-rutinoside (6) exhibited the highest docking scores as effective antitrypanosomal compounds. � 2019, � 2019 Informa UK Limited, trading as Taylor & Francis Group.