Browsing by Author "El-Sehrawi H.M."

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    Synthesis of hydrazide-hydrazone derivatives and their evaluation of antidepressant, sedative and analgesic agents
    (2010) Mohareb R.M.; El-Sharkawy K.A.; Hussein M.M.; El-Sehrawi H.M.; Faculty of Pharmacy; Organic Chemistry Department; October University for Modern Sciences and Arts (MSA); El-Wahat Road; 6 October City; Egypt; Department of Chemistry; Faculty of Science; Cairo University; Giza; A. R; Egypt; Faculty of Pharmacy (Girls); Pharmaceutical Chemistry Department; Al-Azhar University; Nasr City; Cairo; A. R; Egypt
    The reaction of cyanoacetylhydrazine (1) with ?-bromo(4-methoxyacetophenone) (2) gave the hydrazide-hydrazone derivative 3. Compound 3 reacted with either potassium cyanide or potassium thiocyanide to give the cyanide or thiocyanide derivatives 4a or 4b respectively. The reaction of compound 3 with either hydrazine hydrate or phenylhydrazine gave the hydrazine derivatives 6a or 6b respectively. The latter compounds underwent a series of heterocyclization when react with different reagents to give 1,3,4-triazine and pyridine derivatives. The antidepressant, sedative and analgesic activities of the newly synthesized products were evaluated.