Browsing by Author "El-Maraghy C.M."

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Advanced approaches for the treatment and amplification of weak spectral signals produced by critical concentrations in white multicomponent systems
(Elsevier B.V., 2020) Lotfy H.M.; Saleh S.S.; El-Maraghy C.M.; Analytical Chemistry Department; Faculty of Pharmacy; Cairo University; Kasr-El Aini Street; Cairo; 11562; Egypt; Pharmaceutical Chemistry Department; Faculty of Pharmaceutical Sciences & Pharmaceutical Industries; Future University in Egypt; Cairo; 12311; Egypt; Analytical Chemistry Department; Faculty of Pharmacy; October University for Modern Sciences and Arts (MSA); 11787 6th October; Egypt
An analytical investigation was carried out to study the treatment and amplification of the spectral signals produced by critical concentrations with high accuracy and precision using two advanced approaches. The factorized-spectrum approach was applied through two novel methods which were: absorptivity centering technique via both: factorized zero order absorption spectrum (ACT-FSD0 ?A) and factorized ratio spectrum (ACT-FSR?P). The proposed methods were found to be linear in the ranges of (15�100 ?g/mL) and (3�40 ?g/mL) for ASP and MTO, respectively. Those methods were compared to the methods following the geometrical standard addition approach: ratio H-point standard addition method (RHPSAM) and geometrical induced amplitude modulation (GIAM). The approaches were applied for the determination of the minor component metoclopramide in its mixture with the major component aspirin in the challengeable ratio of (1,90) respectively in a white multicomponent system. The results obtained from the proposed approaches were statistically compared with each other. The methods were validated according to ICH guidelines where the results were found to be within the acceptable limits. The methods were found to be accurate and reliable for the determination of metoclopramide critical concentration besides aspirin concentration. The results of single factor ANOVA analysis indicated that there is no significant difference among the developed methods. These methods provided simple resolution of this binary combination from synthetic mixtures and pharmaceutical preparation and can be conveniently adopted for routine quality control analysis. � 2019 Elsevier B.V.
Ion selective membrane electrodes for determination of Citalopram Hydrobromide in drug product and in presence of its degradation products
(Center of Excellence in Electrochemistry, Univ. of Tehran, 2015) Nebsen M.; El-Maraghy C.M.; Salem H.; Amer S.M.; Analytical Chemistry department; Cairo University; Kasr-El Aini Street; Cairo; 11562; Egypt; Pharmaceutical Analytical Chemistry department; Heliopolis University; 3 Cairo Belbeis desert road; El-Horria; Cairo; 2834; Egypt; Analytical Chemistry department; October University for Modern Sciences and Arts (MSA); 6th October city; 11787; Egypt; Pharmaceutical Analytical Chemistry department; Deraya University; Minia; Egypt
This paper presents a comparative study between three sensors developed to determine Citalopram Hydrobromide (CT) in the presence of its alkaline hydrolysis and oxidation induced degradation products using different ion association complexes. Sensor 1 was fabricated using phosphomolybdic acid, Sensor 2 used phosphotungestic acid and sensor 3 used the sodium tetraphenyl borate. Linear responses of CT were obtained within the concentration ranges of 1�10?6 to 1�10?2 mol L-1 for sensor 1 and 2 and 1�10?5 to 1�10?2 mol L-1 for sensor 3 over the pH range of 3.0�6.0. The selectivity coefficients of the developed sensors indicated excellent selectivity for CT. The proposed sensors displayed useful analytical characteristics for the determination of CT in bulk powder, pharmaceutical formulation, and in the presence of its degradation products and thus could be used for stability-indicating methods. The method was validated according to ICH guidelines. Statistical comparison between the results from the proposed method and the results from the reference HPLC method showed no significant difference regarding accuracy and precision. � 2015 by CEE (Center of Excellence in Electrochemistry).
Novel membrane sensors for the determination of quetiapine fumarate in plasma and in presence of its related compounds
(Center of Excellence in Electrochemistry, Univ. of Tehran, 2016) Nebsen M.; El-Maraghy C.M.; Salem H.; Amer S.M.; Cairo University; Analytical Chemistry department; Kasr-El Aini Street; Cairo; 11562; Egypt; Pharmaceutical Analytical Chemistry department; Drug Technology; Heliopolis University; 3 Cairo Belbeis desert road; Horria; Cairo; 2834El; Egypt; Analytical Chemistry department; October University for Modern Sciences and Arts(MSA); 6th October city; 11787; Egypt; Pharmaceutical Analytical Chemistry department; Deraya University; Minia; Egypt
Two sensitive and selective polyvinyl chloride (PVC) matrix membrane sensors were developed and investigated for determination of the cationic drug Quetiapine Fumarate (QTF) in pure form, in plasma and in presence of its two related compounds namely Quetiapine N-oxide and Des-ethanol Quetiapine. The two sensors (? and ??) were developed using sodium tetraphenyl borate as a cation exchanger with dioctyl phthalate (DOP) as a plasticizer. Selective molecular recognition component, ?-cyclodextrin (?-CD), was used as ionophore to improve the selectivity of sensor II. The proposed sensors had a linear dynamic range of 1�10-6 -1�10-2 mol L-1 for sensor ? and 1�10-7 -1�10-2 mol L-1 for sensor ?? with Nernstian slopes of 27.50�0.45 and 39.85�0.3 mV/decade for sensors I and II, respectively over the pH ranges of 2.5-7. The method was validated according to ICH guidelines. Statistical comparison between the results from the proposed method and the results from the reference HPLC method showed no significant difference regarding the accuracy and precision. � 2016, Center of Excellence in Electrochemistry, Univ. of Tehran. All rights reserved.
Rapid validated thin-layer chromatography-densitometry for the simultaneous determination of three co-formulated drugs used for common cold treatment
(Akademiai Kiado Rt., 2019) Fouad M.M.; El-Maraghy C.M.; Analytical Chemistry Department; Faculty of Pharmacy; October University for Modern Sciences and Arts (MSA); Egypt; Analytical Chemistry Department; Faculty of Pharmacy; Al-Azhar University; Egypt
A rapid validated thin-layer chromatography (TLC).densitometric method has been developed for the simultaneous determination of 3 co-formulated drugs used for common cold and cough treatment. The studied drugs are paracetamol, pseudoephedrine, and chlorpheniramine maleate. The separation was achieved using silica gel 60 F254 plates and the developing system of methanol. toluene.acetic acid (44:16:1, v/v). Densitometry scanning was performed at 254 nm. The method was validated as per the International Conference on Harmonization (ICH) guidelines and was successfully applied for the analysis of pharmaceutical preparation containing the cited ternary mixture without interference from excipients. There is no previously published TLC.densitometric method for the determination of the previously mentioned ternary mixture. The suggested method is rapid and of low cost, so it can be used for quality control analysis. 2019 Akadmiai Kiad