Browsing by Author "El-Borady O.M."

Filter results by typing the first few letters
Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    5-Fluorouracil induces plasmonic coupling in gold nanospheres: New generation of chemotherapeutic agents
    (2012) Mohamed M.B.; Adbel-Ghani N.T.; El-Borady O.M.; El-Sayed M.A.; National Institute of Laser Enhanced Sciences (NILES); Cairo University; Giza; Egypt; NanoTech Egypt for Photoelectronics; Dreamland; October city; Egypt; Chemistry Department; Cairo University; Giza; Egypt; Chemistry Department; Modern Science and Arts University; October city; Egypt; Laser dynamics laboratory; Georgia Institute of Technology; Atlanta; United States
    Loading 5- Fluorouracil (5-FU) into gold nanoparticles (AuNPs) could enhance its activity as anticancer drug hugely by enhancing its ability for penetration through the cell membrane. Accordingly, this work is devoted to loading 5-FU into AuNPs surface and studying the binding mechanism of the drug to the surface of the gold nanoparticles. Our finding indicates that new absorption band appears at longer wavelength upon loading 5-FU into gold nanospheres capped with citrate. This near IR band is due to induced surface plasmon coupling via hydrogen bonding between 5-FU and surface capping AuNPs. This leads to great enhancement of the drug action as chemotherapeutic as well as photothermal agents. Factors which affect the binding between 5-FU and the AuNPs such as pH, time after mixing the drug with AuNPs, concentration of the 5-FU, have been studied in detail. Accordingly, the binding interaction is proven to be via hydrogen bonding. Upon the investigation of thermal and photo satiability, the formed composite 5-FU@AuNPs showed high stability towards these factors. The spectral and morphological studies were measured via UV-VIS spectroscopy and Transmission Electron Microscopy (HR-TEM). Remarkable increases in the drug anticancer activity upon loading into AuNPs were observed for the cell viability test of human colon cancer (HCT16). � 2012 Mohamed MB, et al.
  • Thumbnail Image
    Item
    Co(II), Ni(II) and Cu(II) complexes of azo-aminopyrazole ligand: Spectroscopic, crystal structure and quantum chemical calculations
    (Elsevier S.A., 2015) Abdel-Ghani N.T.; Mansour A.M.; Abo El-Ghar M.F.; El-Borady O.M.; Shorafa H.; Chemistry Department; Faculty of Science; Cairo University; Gamaa Street; Giza; 12613; Egypt; Chemistry Department; Modern Science and Arts University; October City; Egypt; Institut f�r Chemie und Biochemie; Freie Universit�t Berlin; Fabeckstrasse 34-36; Berlin; 14195; Germany
    Reaction of 5-Methyl-4-(2-nitro-phenylazo)-2-phenyl-2H-pyrazol-3-ylamine (H2L) with Co(II), Ni(II) and Cu(II) salts affords complexes of the type [M(HL)2], which were characterized by elemental analysis, FT IR, UV-Vis, magnetic susceptibility, conductance measurements and single crystal X-ray diffraction. H2L crystallizes in a monoclinic space group C2/c, while the Cu(II) complex crystallizes in the triclinic P1�(2) space group. H2L behaves as a mono-negatively bidentate ligand via NN and NH-. Comparison between the crystal and the optimized data at DFT/B3LYP/6-31G(d) level of theory was discussed. Time-dependent DFT calculations were performed to assign the electronic spectra. The natural charge of NiII is more reduced than CoII and CuII, which suggests the higher complexation ability of H2L toward the former ion. � 2015 Published by Elsevier B.V.