Browsing by Author "Badawey A.M."

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    Application of three novel spectrophotometric methods manipulating ratio spectra for resolving a pharmaceutical mixture of Chlorphenoxamine hydrochloride and Caffeine
    (2013) Mohsen A.M.; Lotfy H.M.; Badawey A.M.; Salem H.; Elkhateeb S.Z.; Analytical Chemistry Department; MSA University; 6th October City; Giza; Egypt
    Three spectrophotometric methods are presented for the determination of a binary mixture of Chlorphenoxaminehydrochloride (CPX) and Caffeine (CAF) in laboratory prepared mixture and pharmaceutical dosage form without prior separation. Method (I)is an extended ratio subtraction method (EXRSM) coupled with ratio subtraction method (RSM), which depends on subtraction of the plateau values from the ratio spectrum. Method (II)is a ratio difference spectrophotometric method (RDSM), which depends on the difference in value between two different wavelengths of the ratio spectrum. Method (III) is a mean centering of ratio spectra (MCR). Mathematical explanation of the three methods is illustrated. Calibration curves of the three methods are linear over the concentration ranges of 4-24 ?gml-1and 2-24 ?gml-1for CPX and CAF, respectively.The three methods proved to be simple, specific, accurate and precise. Solvent used is double distilled water. The three methods are validated as per the ICH guidelines where accuracy, precision, repeatability and robustness are found to be within the acceptable limits.
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    Development and validation of smart spectrophotometric-chemometric methods for the simultaneous determination of chlorpheniramine maleate and etilefrine hydrochloride in bulk powder and in dosage form combinations
    (IJPPS, 2014) Mohsen A.M.; Badawey A.M.; Shehata M.A.; Elkhateeb S.Z.; Analytical Chemistry Department; MSA University; 6th October City; Giza; Egypt; Analytical Chemistry Department; Cairo University; KasrElinist; 11562; Cairo; Egypt
    This paper describes threesensitive, accurate and precise chemometricspectrophotometricmethods for the simultaneous determination of chlorpheniramine maleate (CPM) and etilefrine hydrochloride (ETF)in bulk powder and capsules without prior separation. Multivariate calibration chemometric methods are proposed for simultaneous determination of CPMandETF. The chemometric methods applied are classical least squares (CLS),principal component regression (PCR) and partial least squares (PLS). These approaches aresuccessfully applied to quantify both drugs using the information included in the absorption spectra of appropriate solutions.In these multivariatemethods, calibration sets of standard samples composed of different mixtures of CPMand ETFhave been designed. The methods were validated according to the International Conference on Harmonization (ICH) guidelines. The specificity of the proposed methods was tested using laboratory-prepared mixtures. The developed methods were successfully applied for the determination of CPM and ETF in bulk powder and dosage form combination.