Browsing by Author "Abdelfattah, Mohamed S"

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    Green Synthetized Selenium Nanoparticles Using Syzygium aromaticum (Clove) Extract Reduce Pentylenetetrazol-Induced Epilepsy and Associated Cortical Damage in Rats
    (Multidisciplinary Digital Publishing Institute (MDPI), 2023-01) Othman, Mohamed S; Obeidat, Sofian T; Aleid, Ghada M; Al-Bagawi, Amal H; Fareid, Mohamed A; Abdel Hameed, Reda; Mohamed, Kareem M; Abdelfattah, Mohamed S; Fehaid, Alaa; Hussein, Manal M; Aboelnaga, Shimaa M. H; Abdel Moneim, Ahmed E
    We aimed to investigate the potential anticonvulsant effect of green synthetized sele- nium nanoparticles (SeNPs) using Syzygium aromaticum extract (SAE) (SAE-SeNPs) against epileptic seizures and cortical damage induced by pentylenetetrazole (PTZ) injection in rats and its mechanism. A total of 84 rats were divided into six groups; control, PTZ-exposed group, SAE + PTZ-treated group, sodium selenite (Na2SeO3 ) + PTZ-treated group, SAE-SeNPs + PTZ-treated group, and diazepam + PTZ-treated group. SAE-SeNPs significantly increase (p < 0.05) the latency time to seizures and reduce both the seizure duration and death rate, which were enhanced by the PTZ injection. SAE-SeNPs counteracted the PTZ-induced changes in the oxidants and antioxidants. Furthermore, SAE-SeNPs significantly restored (p < 0.05) the pro-inflammatory cytokines (interleukin-1β, interleukin-6, and tumor necrosis factor-α) to their normal levels and suppressed the activity of the glial fibrillary acidic protein showing their inhibitory effect on the epilepsy-associated inflammation. In addition, SAE-SeNPs significantly reduced (p < 0.05) PTZ-induced cortical cell apoptosis, as revealed by a reduction in the pro-apoptotic Bax and caspase-3 levels, and an elevation of the anti-apoptotic Bcl-2 level. Moreover, SAE-SeNPs significantly modulate (p < 0.05) the PTZ-induced changes in the neuro- transmitter norepinephrine level and acetylcholinesterase enzymatic activity. These data concluded the anticonvulsant activity of SAE-SeNPs via their antioxidant, anti-inflammatory, and anti-apoptotic effects, along with their ability to modulate neurotransmitters.
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    Protective effect of Allium atroviolaceum-synthesized SeNPs on aluminum-induced brain damage in mice
    (Walter de Gruyter GmbH, 2022-11) Othman, Mohamed S; Obeidat, Sofian T; Aleid, Ghada M; Al-Bagawi, Amal H; Fehaid, Alaa; Habotta, Ola A; Badawy, Mohamed M; Elganzoury, Sara S; Abdalla, Mohga S; Abdelfattah, Mohamed S; Daiam, Mohamed A; Abdel Moneim, Ahmed E
    reduction in AChE as compared with the AlCl3 group. Therefore, our results indicate that SeNPs-AaE has a potential neuroprotective effect against Al-mediated neurotoxic effects because of its powerful antioxidant, anti-inflammatory, anti-apoptotic, and neuromodulatory activities.