Faculty Of Pharmacy Research Paper

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    Insights into Eucalyptus genus chemical constituents, biological activities and health-promoting effects
    (Elsevier Ltd, 2019) Salehi B.; Sharifi-Rad J.; Quispe C.; Llaique H.; Villalobos M.; Smeriglio A.; Trombetta D.; Ezzat, Shahira M; Salem M.A.; Zayed A.; Salgado Castillo C.M.; Yazdi S.E.; Sen S.; Acharya K.; Sharopov F.; Martins N.; Student Research Committee; School of Medicine; Bam University of Medical Sciences; Bam; Iran; Zabol Medicinal Plants Research Center; Zabol University of Medical Sciences; Zabol; Iran; Instituto de EtnoFarmacolog�a; Facultad de Ciencias de la Salud; Universidad Arturo Prat; Avda. Arturo Prat 2120; Iquique; 1110939; Chile; Department of Chemical; Biological; Pharmaceutical and Environmental Sciences; University of Messina; Italy; Department of Pharmacognosy; Faculty of Pharmacy; Cairo University; Kasr El-Aini Street; Cairo; 11562; Egypt; Department of Pharmacognosy; Faculty of Pharmacy; October University for Modern Sciences and Arts (MSA); 6th October 12566; Egypt; Department of Pharmacognosy; Faculty of Pharmacy; Menoufia University; Gamal Abd El Nasr st.; Shibin Elkom; Menoufia32511; Egypt; Department of Pharmacognosy; College of Pharmacy; Tanta University; Elguish Street; Tanta; 31527; Egypt; Facultad de Medicina; Universidad del Azuay; Cuenca; Ecuador; Department of Plant and Soil Sciences; University of PretoriaGauteng 0002; South Africa; Molecular and Applied Mycology and Plant Pathology Laboratory; Department of Botany; University of Calcutta; Kolkata; 700019; India; Department of Botany; Fakir Chand College; Diamond Harbour; West Bengal743331; India; Department of Pharmaceutical Technology; Avicenna Tajik State Medical University; Rudaki 139; Dushanbe; 734003; Tajikistan; Faculty of Medicine; University of Porto; Alameda Prof. Hernni Monteiro; Porto; 4200-319; Portugal; Institute for Research and Innovation in Health (i3S); University of Porto; Porto; 4200-135; Portugal
    Background: Eucalyptus genus members have received a great interest worldwide for their antibacterial, antiviral, antifungal, anti-inflammatory and insect-repellent properties for cosmetic, pharmaceutical, nutraceutical and furniture purposes. Indeed, the application of Eucalyptus essential oil in cosmetic and personal hygiene products is gradually increasing. Also, it has been widely used in the traditional medicine for centuries, in the treatment of respiratory diseases, common cold, influenza, and sinus congestion. Scope and approach: This review addressed botanical and ethnopharmacological aspects of Eucalyptus plants, as also its in vitro and in vivo pharmacological activities, and current insights with regards to clinical efficacy and safety. Key findings and conclusions: Eucalyptol (1,8-cineole) is the main component present in Eucalyptus oils. According to the previously reported uses of Eucalyptus oils and extracts, there is urgently required further in vivo studies with the distinct Eucalyptus constituents to reveal the secrets beyond the traditional uses for treatment of a wide spectrum of ailments. A great attention has also been given for its nanotechnological applications by food and pharmaceutical industries. Nanoemulsions containing Eucalyptus globulus oil have been recognized for its antimicrobial and antibiofilm effects against gram-negative bacteria and the major microorganism responsible for causing fungal infections worldwide (Candida albicans). Moreover, eucalyptol does not present genotoxicity or carcinogenicity. Subacute hepatotoxic and nephrotoxic effects in animal models have been stated after application of high doses, higher than the estimated LD50 (2400 mg/kg b.w. In rats). However, an in-deep risk assessment on further exposure and toxicity data is highly needed. 2019 Elsevier Ltd