ANTI-WRINKLE ACTIVITY AND UPLC-MS/MS METABOLIC PROFILING OF POMEGRANATE AND GRAPE SEEDS EXTRACTS

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dc.contributor.author Odah, Sally M.
dc.contributor.author Salama, Maha M.
dc.contributor.author Aziz, Wafaa M.
dc.contributor.author El-Alfy, Taha S.
dc.contributor.author Ezzat, Shahira M
dc.date.accessioned 2020-09-12T11:10:34Z
dc.date.available 2020-09-12T11:10:34Z
dc.date.issued 08/01/2020
dc.identifier.other https://doi.org/10.13040/IJPSR.0975-8232.11(8).3679-89
dc.identifier.uri http://repository.msa.edu.eg/xmlui/handle/123456789/3772
dc.description.abstract UV irradiation is one of the main causes of what is known as photoaging characterized by loss of skin elasticity and the appearance of wrinkles. In this study, the anti-wrinkle activity of grape seed extract (GSE) and Pomegranate seed extract (PSE) was studied through evaluation of their in-vitro antioxidant, anti-tvrosinase and in-vivo anti-wrinkle activity in UVB-irradiated mice through topical application of PSE and GSE at 50 mg/kg/twice a week for 15 weeks. The total phenolic content of PSE and GSE was 2.1375 and 5.9625 mg GAE/g extract, respectively. PSE and GSE also showed DPPH scavenging activity with IC50 of 37.9 and 29.9 mu g/mL, respectively. PSE and GSE showed anti-tyrosinase activity with IC50 of 115 and 107.75 mu g /mL, respectively, while that of Kojic acid is 17.45 mu g /mL. In UVB-irradiated mice, the increased expression of metaloproteinase (MMP-2) was significantly inhibited by PSE and GSE where their activities exceeded that of the standard turmeric extract (TME). The topical application of PSE, GSE, and TME of the UVB radiated groups prevented the increase in the thickness of the epidermis induced by UVB. UPLC-MS/MS profiling of both extracts led to the identification of 43 phenolic compounds of different classes. We can conclude that the anti-wrinkle activity of both extracts was attributed to their high phenolic content and the antioxidant potential of both extracts. Therefore, the seeds of pomegranate and grapes, which are considered as waste products, could be incorporated in cosmeceutical skincare products after further clinical trials en_US
dc.description.uri https://www.scimagojr.com/journalsearch.php?q=21101041727&tip=sid&clean=0
dc.language.iso en_US en_US
dc.publisher INT JOURNAL PHARMACEUTICAL SCIENCES en_US
dc.relation.ispartofseries INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH;Volume: 11 Issue: 8 Pages: 3679-3689
dc.subject MMP-2 en_US
dc.subject Waste products en_US
dc.subject Antiaging en_US
dc.subject Punica granatum en_US
dc.subject Vitis venifera en_US
dc.title ANTI-WRINKLE ACTIVITY AND UPLC-MS/MS METABOLIC PROFILING OF POMEGRANATE AND GRAPE SEEDS EXTRACTS en_US
dc.type Article en_US
dc.identifier.doi https://doi.org/10.13040/IJPSR.0975-8232.11(8).3679-89
dc.Affiliation October University for modern sciences and Arts (MSA)


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