Adiponectin and pro-inflammatory cytokines in obese diabetic boys

El-Mesallamy H.O.; Hamdy N.M.; Ibrahim S.M.

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Adiponectin and pro-inflammatory cytokines in obese diabetic boys

El-Mesallamy H.O.; Hamdy N.M.; Ibrahim S.M.

Full Text link: https://t.ly/ZEKlB

Date issued: 2011

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Doi: https://doi.org/10.1007/s13312-011-0125-7 PubMed ID 22080689

Series Info: Indian Pediatrics
48

Type: Article

Keywords: Adiponectin , Children , Egypt , Inflammation , Obesity , sE-selectin , Type 2 Diabetes , adiponectin , C reactive protein , endothelial leukocyte adhesion molecule 1 , glucose , high density lipoprotein cholesterol , insulin , interleukin 1beta , lipid , monocyte chemotactic protein 1 , nitric oxide , adolescent , adult , adulthood , age distribution , article , body mass , child , clinical article , controlled study , glucose blood level , glucose metabolism , human , inflammation , insulin resistance , male , non insulin dependent diabetes mellitus , obesity , protein blood level , school child , Adiponectin , Adolescent , Adult , Body Mass Index , C-Reactive Protein , Case-Control Studies , Chemokine CCL2 , Child , Cytokines , Diabetes Mellitus, Type 2 , E-Selectin , Humans , Male , Nitric Oxide , Obesity

Abstract:

Adiponectin serum levels were significantly lower in obese diabetic than in non-obese healthy boys (P<0.001). Circulating soluble E-selectin levels was significantly higher in obese diabetic boys than the healthy non-obese (P<0.01). There were significant inverse correlations between adiponectin and sE-selectin, hsCRP, IL-1?, and MCP-1 and positively with NOx. We conclude that sE-selectin and MCP-1 may represent a link between obesity and related co-morbidities in children and adults.