The biological activity of conocarpus erectus extracts and their applications as cytotoxic agents

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dc.contributor.author Safwat G.M.
dc.contributor.author Hamed M.M.
dc.contributor.author Helmy A.T.
dc.contributor.other Faculty of Biotechnology
dc.contributor.other October University for Modern Sciences and Arts
dc.contributor.other Giza
dc.contributor.other Egypt; Theodor Bilharz Research Institute
dc.contributor.other Giza
dc.contributor.other Egypt
dc.date.accessioned 2020-01-09T20:40:52Z
dc.date.available 2020-01-09T20:40:52Z
dc.date.issued 2018
dc.identifier.issn 18278620
dc.identifier.uri https://t.ly/ep3we
dc.description Scopus
dc.description MSA Google Scholar
dc.description.abstract Essential oils are found to have multiple active components which can show in vitro cytotoxic action against various cancerous cell lines. This study reports the in vitro cytotoxic effects of the essential oil from Conocarpus erectus (Combretaceae) growing wild in Egypt. Water-distilled essential oil of C. erectus was examined for its cytotoxic effects using a modified brine shrimp and MTT assays. Fresh leaves aerial part of C. erectus was subjected to hydro distillation using a Clevenger-type apparatusvolatile to obtain its volatile oil. Cytotoxicity of the essential oil was measured against HepG2 cancer cells and brine shrimps larva. The essential oil 50% cytotoxic concentrations were found to be 33�g/ml and 8.7�g/ml against brine shrimp and human liver carcinoma HepG2 cell line, respectively; thus the volatile oil displayed good cytotoxic action against the human tumor cell line. Moreover, C. erectus methanol extract was very effective; it exhibited cytotoxic activity against brine shrimp larva within IC50 value of 15�g/ml. The investigation from GC Mass, led to the identification of 12 constituents, representing 97.53% of the total oil, of which the major chemical constituents were identified by gas chromatography mass spectrometry as being rich in 3-(2,2 dimethylpropylid ene)bicyclo[3.3.1]nonane-2,4-dione (3) (67.12%), (decanoic acid derevatives (11) (7.77%), 22-tritetracontanone (12) (6.03%), 1-octanol, 2-butyl-(2) (5.51%) and oleic acid (6) (4.33%). This is the first report on anticancer potential and separation of essential oils from C. erectus. The findings of this study necessitate the need for further consideration of this essential oil in anti-neoplastic chemotherapy. � 2018, SILAE (Italo-Latin American Society of Ethnomedicine). All rights reserved. en_US
dc.language.iso English en_US
dc.publisher Elsevier
dc.publisher SILAE (Italo-Latin American Society of Ethnomedicine) en_US
dc.relation.ispartofseries Pharmacologyonline
dc.relation.ispartofseries 2
dc.subject October University for Modern Sciences and Arts
dc.subject University for Modern Sciences and Arts
dc.subject MSA University
dc.subject جامعة أكتوبر للعلوم الحديثة والآداب
dc.subject Conocarpus erectus en_US
dc.subject Cytotoxicity en_US
dc.subject Hepg2 cells en_US
dc.subject Mtt assay en_US
dc.subject Phytochemistry en_US
dc.subject Volatile oil en_US
dc.subject Conocarpus erectus extract en_US
dc.subject decanoic acid en_US
dc.subject essential oil en_US
dc.subject methanol en_US
dc.subject oleic acid en_US
dc.subject plant extract en_US
dc.subject unclassified drug en_US
dc.subject animal experiment en_US
dc.subject Artemia en_US
dc.subject Article en_US
dc.subject biological activity en_US
dc.subject Combretaceae en_US
dc.subject Conocarpus erectus en_US
dc.subject controlled study en_US
dc.subject crustacean larva en_US
dc.subject cytotoxicity en_US
dc.subject distillation en_US
dc.subject drug identification en_US
dc.subject drug mechanism en_US
dc.subject Egypt en_US
dc.subject Hep-G2 cell line en_US
dc.subject human en_US
dc.subject human cell en_US
dc.subject IC50 en_US
dc.subject in vitro study en_US
dc.subject mass fragmentography en_US
dc.subject MTT assay en_US
dc.subject nonhuman en_US
dc.subject plant leaf en_US
dc.subject toxic concentration en_US
dc.title The biological activity of conocarpus erectus extracts and their applications as cytotoxic agents en_US
dc.type Article en_US
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dcterms.source Scopus
dc.Affiliation October University for modern sciences and Arts (MSA)


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