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Browsing Faculty of Biotechnology Research Paper by Title

Now showing items 285-304 of 471

Khalas date flavonoids inhibited cell viability, induced apoptosis and expression of the pro-autophagy LC3-B gene in human hepatocellular carcinoma cells (HepG2)

AL-Ghamdi, Maryam Abdu; Alsulami, Rawyah Radi; Bakkar, Ashraf; Kumosani, Taha Abullah; Barrbour, Elie Kamil; Abulnaja, Khalid Omar; Huwait, Etimad; Moselhy, Said Salama (Taylor and Francis Ltd., 2022-11)

Autophagy is a protective mechanism important in human dis- eases as cancer. We evaluated the impact of khalas date extract (KDE) (20-60 mg/mL) on cell viability, morphological changes, DNA fragmentation and gene ...
Knockdown of WEE1 Gene Induces Cytotoxic Effects in Hairy Cell Leukemia

El-Khazragy, Nashwa; Bakkar, Ashraf; Elnakib, Mostafa (Elsevier, 2021-09)

Clinical Lymphoma Myeloma and Leukemia Volume 21, Supplement 1, September 2021, Page S325 Acute Myeloid Leukemia CLL-393: Knockdown of WEE1 Gene Induces Cytotoxic Effects in Hairy Cell Leukemia Author links open overlay ...
Label-Free Infrared Spectral Histology of Skin Tissue Part II: Impact of a Lumican-Derived Peptide on Melanoma Growth

Brézillon, S; Untereiner, V; Mohamed, H.T; Ahallal, E; Proult, I; Nizet, P; Boulagnon-Rombi, C; Sockalingum, G.D (Frontiers Media S.A., 5/29/2020)

Melanoma is the most aggressive type of cutaneous malignancies. In addition to its role as a regulator of extracellular matrix (ECM) integrity, lumican, a small leucine-rich proteoglycan, also exhibits anti-tumor properties ...
Liraglutide in Treatment of Diabetes Mellitus Type 2: Systematic Review and Bibliometric Analysis Over The Last Two Decades

Kamal, Manar Ahmed; Al-Arawi, Raneem Mahmoud (Saunders, 2022-03)

Background: Type 2 diabetes mellitus (T2DM) is a chronic progressive metabolic disorder and liraglutide is one of the glucagon-like peptide-1 (GLP-1) agonists that are used to decrease glucose levels in the blood and help ...
Local anaesthetic potential, metabolic profiling, molecular docking and in silico ADME studies of Ocimum forskolei, family Lamiaceae

Maher Zahran, Eman; Ramadan Abdelmohsen, Usama; M Shalash, Mahmoud; Ezzat Khalil, Hany; . Alaraby Salem, M (Taylor and Francis, 2019)

The present study aimed to detect the bioactive metabolites from Ocimum forskolei aerial parts which are responsible for the local anaesthetic activity of the ethyl acetate fraction. Following a bioassay-guided fractionation, ...
m 6 A modification of HSATIII lncRNAs regulates temperature‐dependent splicing

Ninomiya, Kensuke; Iwakiri, Junichi; Aly, Mahmoud Khamis; Sakaguchi, Yuriko; Asai, Shungo Kiyoshi; Suzuki, Tsutomu; Hirose, Tetsuro (EMBO PRESS, 2021)

Nuclear stress bodies (nSBs) are nuclear membraneless organelles formed around stress-inducible HSATIII architectural long noncoding RNAs (lncRNAs). nSBs repress splicing of hundreds of introns during thermal stress recovery, ...
Melatonin loaded poly(lactic‑co‑glycolic acid) (PLGA) nanoparticles reduce infammation, inhibit apoptosis and protect rat’s liver from the hazardous efects of CCL4

Farid, Alyaa; Michael, Valina; Safwat, Gehan (Nature Publishing Group, 2023-12)

Liver is an important organ that carries out major important functions including the detoxifcation of harmful chemicals. Numerous studies have lately focused on the impact of various substances, such as chemical ...
Melatonin relieves diabetic complications and regenerates pancreatic beta cells by the reduction in NF-kB expression in streptozotocin induced diabetic rats Melatonin: anti-diabetic drug

Farid, Alyaa; Moussa, Passant; Youssef, Manar; Haytham, Merna; Shamy, Ali; Safwat, Gehan (Elsevier, 22/05/2022)

Melatonin, a pleiotropic hormone, has many regulatory effects on the circadian and seasonal rhythms, sleep and body immune system. It is used in the treatment of blind circadian rhythm sleep disorders, delayed sleep phase ...
A Meta-Analysis of the Relationship between FGFR3 and TP53 Mutations in Bladder Cancer

Neuzillet, Yann; Paoletti, Xavier; Ouerhani, Slah; Mongiat-Artus, Pierre; Soliman, Hany; de The, Hugues; Sibony, Mathilde; Denoux, Yves; Molinie, Vincent; Herault, Aurelie; Lepage, May-Linda; Maille, Pascale; Renou, Audrey; Vordos, Dimitri; Abbou, Claude-Clement; Bakkar, Ashraf; Asselain, Bernard; Kourda, Nadia; El Gaaied, Amel; Leroy, Karen; Laplanche, Agnes; Benhamou, Simone; Lebret, Thierry; Allory, Yves; Radvanyi, François (Public Library of Science, 2012)

TP53 and FGFR3 mutations are the most common mutations in bladder cancers. FGFR3 mutations are most frequent in low-grade low-stage tumours, whereas TP53 mutations are most frequent in high-grade high-stage tumours. Several ...
Metal-tolerant morganella morganii isolates can potentially mediate nickel stress tolerance in Arabidopsis by upregulating antioxidative enzyme activities

Naqqash, Tahir; Aziz, Aeman; Baber, Muhammad; Shahid, Muhammad; Sajid, Muhammad; Emanuele, Radicetti; Gaafar, Abdel-Rhman Z; Hodhod, Mohamed S; Haider, Ghulam (Landes Bioscience, 2024-03)

Plant growth-promoting rhizobacteria (PGPRs) have been utilized to immobilize heavy metals, limiting their translocation in metal contaminated settings. However, studies on the mechanisms and interactions that elucidate ...
Microbial dynamics and dehydrogenase activity in tomato (Lycopersicon esculentum Mill.) rhizospheres: Impacts on growth and soil health across different soil types

Suliman, Kamal Hassan; Gaafar, Abdel-Rhman Z; Abdelmalik, Abdelmalik M; AlMunqedhi, Bandar M; Elzein, Abdalla; Hodhod, Mohamed S (Walter de Gruyter GmbH, 2024-03)

The dehydrogenase activity (DHA) in the rhizospheres of tomatoes grown in different soil types – Khor Abu-Habil (KA), Bara (B), and Greenhouse (Gr) – in North Kordofan, Sudan, was determined. In addition, the abundance ...
Microbial psychology: Behavior, associative learning, and relation to antibiotic resistance

Shalapy, Mohamed; Darwish, Amira M. Galal; Mbarek, Hasna Nait; Gonzlez, Tamara; Hajjaj, Hassan; Gomaa, Ahmed E; Hafez, Elsayed E (MediPoeia, 2023-02)

Single-cell intelligence is a recent terminology suggested since it was clear that “biological intelligence” is deeply rooted in a genetic basis. The possible applications of the term conception are many where noncoding ...
Microbial tyrosinase: Biochemical, molecular properties and pharmaceutical applications

El-Sayed, Ashraf S.A; Maamoun, Hanaa Salah; Rabie, Gamal H; Morsy, Yara; Ali, Mostafa G; Rady, Amgad M (Oriental Scientific Publishing Company, 2021-10)

Tyrosinase is a copper-containing monooxygenase involved in the catalysis of the hydroxylation and oxidation reaction of monophenols and diphenols, respectively, into O-quinones intermediates. Tyrosinase is mainly involved ...
microRNA 338-3p exhibits tumor suppressor role and its down-regulation is associated with adverse clinical outcome in prostate cancer patients

Bakkar A.; Alshalalfa M.; Petersen L.F.; Abou-Ouf H.; Al-Mami A.; Hegazy S.A.; Feng F.; Alhajj R.; Bijian K.; Alaoui-Jamali M.A.; Bismar T.A. (Springer Netherlands, 2016)

MicroRNAs (miRNAs) are small non-coding RNAs that function in transcriptional and post-transcriptional regulation of gene expression. Several miRNAs have been implicated in regulating prostate cancer (PCa) progression. ...
MicroRNA-155 mediates multiple gene regulations pertinent to the role of human adipose-derived mesenchymal stem cells in skin regeneration

Shahin, Hady; Belcastro, Luigi; Das, Jyotirmoy; Grigoriadi, Marina Perdiki; Saager, Rolf B; Steinvall, Ingrid; Sjöberg, Folke; Olofsson, Pia; Elmasry, Moustafa; El-Serafi, Ahmed T (Frontiers Media S.A., 2024-03)

Introduction: The role of Adipose-derived mesenchymal stem cells (AD-MSCs) in skin wound healing remains to be fully characterized. This study aims to evaluate the regenerative potential of autologous AD-MSCs in a non-healing ...
Microsatellite instability analysis in bladder cancer in Egypt

Mamdouh, S (WILEY-BLACKWELL, 2012)
miR-148a and miR-30a limit HCV-dependent suppression of the lipid droplet protein, ADRP, in HCV infected cell models

El-Ekiaby N.M.; Mekky R.Y.; Riad S.E.; Elhelw D.S.; El-Sayed M.; Esmat G.; Abdelaziz A.I. (John Wiley and Sons Inc., 2017)

Hepatitis C Virus (HCV) promotes lipid droplet (LD) formation and perturbs the expression of the LD associated PAT proteins ADRP and TIP47, to promote its own lifecycle. HCV enhances TIP47 and suppresses ADRP by displacing ...
miRNAs: novel noninvasive biomarkers as diagnostic and prognostic tools in neonatal sepsis

El-Khazragy, Nashwa; Mostafa, Mohamed Fathalla; Elnakib, Mostafa; Hemida, Eman H.A; Salah, Amira; Fawzy, Nesma Mohamed; Safwat, Gehan; Emam, Mennatallah M; Mahran, Nievin Ahmed; Rabie, Dina; Mohamed, Noura Mostafa (Elsevier Inc, 2023-08)

Neonatal sepsis is known as a clinical syndrome that is character- ized by signs or symptoms of infection within the first 28 days fol- lowing delivery, and it can be confirmed by the isolation of the causative pathogen ...
miRNome and Proteome Profiling of Human Keratinocytes and Adipose Derived Stem Cells Proposed miRNA-Mediated Regulations of Epidermal Growth Factor and Interleukin 1-Alpha

Shahin, Hady; Abdallah, Sallam; Das, Jyotirmoy; He, Weihai; El-Serafi, Ibrahim; Steinvall, Ingrid; Sjöberg, Folke; Elmasry, Moustafa; El-Serafi, Ahmed T (Multidisciplinary Digital Publishing Institute (MDPI), 2023-03)

Wound healing is regulated by complex crosstalk between keratinocytes and other cell types, including stem cells. In this study, a 7-day direct co-culture model of human keratinocytes and adipose-derived stem cells (ADSCs) ...
Mitigation of environmental expense microbial induced corrosion using novel synthesized Schiff base cationic surfactants

Kobisy, Atef S. (WILEY, 11/02/2020)

Background Sulfate reducing bacteria are considered as the major cause of microbial induced corrosion. It contributes to a lot of environmental and other major expense industrial problems in petroleum industry. Thus, there ...

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