MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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    Nanoformulation of pomegranate peel extract enhances anti-psoriatic efficacy in a rat model
    (Nature Research, 2026-03-04) Mohamed M. Zid; Alyaa Farid; Gehan Safwat; Ahmed A. El-Sherif
    Psoriasis is a chronic inflammatory disease affecting 2% of the global population. Current treatments (e.g., corticosteroids and phototherapy) face limitations such as adverse effects and poor bioavailability, necessitating safer, more effective alternatives. Pomegranate (Punica granatum L.) peel, rich in bioactive compounds with antioxidant and anti-inflammatory properties, holds therapeutic potential but suffers from low stability and solubility. Here, we developed pomegranate peel extract nanoparticles (PGNPs) to overcome these limitations and evaluated their efficacy in psoriasis management. Pomegranate peel extract (PGE) was prepared and transformed into PGNPs via acid hydrolysis. Nanoparticles were characterized for size, stability, and bioactivity. In vitro assays assessed cytotoxicity, antioxidant (DPPH), and anti-inflammatory (hemolysis inhibition) effects. In vivo efficacy was tested in imiquimod-induced psoriatic rats (n = 20) divided into negative control (group I), untreated psoriasis (group II), PGE-treated (200 mg/kg, group III), and PGNPs-treated (100 mg/kg, group IV). Outcomes included oxidative stress markers (MDA, SOD, CAT, and GSH), cytokines (IL-6, IL-17, IFN-γ, and IL-10), and histopathology. PGNPs exhibited superior stability (size: 87–91 nm; zeta potential: +41–44 mV) and lower cytotoxicity than PGE (15.2% vs. 31.2% at 1000 µg/mL). In vitro, PGNPs showed higher antioxidant (96.63% DPPH scavenging) and anti-inflammatory (94.66% hemolysis inhibition) activity. In vivo, PGNPs reduced psoriatic lesions more effectively than PGE, normalizing oxidative stress (MDA: 7.26 vs. 12.22 nmol/g tissue) and inflammatory cytokines (IL-17: 102.20 vs. 123.40 pg/g tissue; IFN-γ: 204.40 vs. 216.80 pg/g tissue). Histopathology confirmed enhanced skin regeneration with PGNPs. PGNPs demonstrated enhanced bioavailability, stability, and therapeutic efficacy over crude extract, significantly mitigating psoriasis-like inflammation in rats. These findings highlight PGNPs as a promising nanotherapy for psoriasis, warranting further clinical exploration.
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    Electrifying Brands: The Role of Social Innovation in E-Vehicle Equity
    (جامعة المنوفية, 2026-02-25) Yasser Halim; Hazem Halim; Ahmed Maree
    Purpose : This study aims to explore the impact of Corporate Social Innovation (CSI) on brand equity, specifically within the electric vehicle (E-vehicle) industry. As sustainability becomes increasingly central to business strategy, understanding how socially innovative practices influence brand perception and value is crucial. Design/methodology/approach : A mixed-method approach was employed. Secondary data were gathered from relevant academic literature, while primary data were collected through in-depth expert interviews and an online questionnaire answered by 234 respondents. The data were analyzed using SPSS, applying ordinal logistic regression and Spearman's correlation to examine relationships between CSI dimensions and brand equity components. Findings : The results confirm a significant positive impact of CSI on brand equity in the E-vehicle sector. Key CSI dimensions—social awareness, performance, and sustainability—were found to contribute to enhanced brand perception, differentiation, and customer engagement. Originality/value : This research contributes to the limited literature on CSI in emerging markets by applying the concept to the rapidly growing E-vehicle industry in Egypt. It provides practical insights for firms aiming to enhance brand equity through socially innovative practices aligned with sustainable development goals.
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    A low profile and wideband textile metasurface-based circular polarized antenna for wearable applications
    (Elsevier GmbH, 2026-05-01) Mohamed El Atrash; Nourhan T. Hassan; Mahmoud A. Abdalla
    A wideband, low profile, compact, and Circularly Polarized (CP) slot antenna loaded by a metasurface structure array is introduced for wearable usage. The whole structure is realized using textile materials. By etching two square slots in diagonal geometry and engraving a U-shaped slot off the Co-Planar Waveguide (CPW) ground, CP was attained along with enhancement in the 3 dB-Axial Ratio Bandwidth. The proposed CP antenna radiates from 1.35 GHz to 4 GHz, which is the impedance bandwidth; thus, covering the 2.45 GHz Industrial, Scientific, and Medical (ISM)-band. The Axial Ratio (AR) bandwidth varies from 1.6 GHz to 2.5 GHz. As such, the effective operational bandwidth for the proposed CP antenna is 1.6 GHz to 2.5 GHz. The antenna electrical size is 0.33λ0 × 0.37λ0 at 2.45 GHz, highlighting its compactness. To achieve low Specific Absorption Rate (SAR), a textile-based 2 × 2 metasurface structure array is loaded at the back of the CP antenna. Wideband operation was preserved after the integration process with the advantage of reducing the specific absorption rate by 99%, while achieving gain improvements over the wideband frequency band. Fabrications were conducted manually, yet the tested outcomes agreed with the software-generated results. The designed antenna has very good competitive results compared to the literature antennas.
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    Effect of Bioptron light therapy on dryness of eyes in postmenopausal women: a randomized controlled trial
    (Springer London, 2026-02-04) Ehab Mohamed Elsayed Saad; Sara Magdy Ahmed; Amel Mohamed Yousef; Elham Shahat Hassan
    To examine the short-term therapeutic effects of Bioptron light therapy (BLT) on dry eye disease (DED) in postmenopausal women. Sixty postmenopausal women diagnosed with DED, aged 50–62 years with a body mass index ≤ 30 kg/m², were randomly assigned to two equal groups. The Bioptron group (n = 30) received BLT for 10 min, twice weekly, along with an educational program for four weeks. The control group (n = 30) received the same educational program only. Outcomes were measured using Schirmer’s test (Schirmer I) for basal tear secretion, Tear Break-Up Time (TBUT) for tear film stability, and the Dry Eye-related Quality of Life Score (DEQS) for quality of life (QOL). Both groups exhibited significant improvements post-treatment compared to pre-treatment in all variables, with greater percentage changes from baseline in the BLT group. Between-group comparisons revealed significantly higher improvements in the BLT group: Schirmer’s test (Schirmer I) improved by MD = 8.7 (95% CI: 7.64–9.76; p = 0.001), TBUT by MD = 2.97 (95% CI: 1.7–4.3; p = 0.007), and DEQS decreased by MD = − 24.1 (95% CI: −37 to − 17.1; p = 0.002). Compared with standardized education alone, adjunctive Bioptron light therapy significantly enhanced tear secretion, tear film stability, and patient-reported symptoms, suggesting its potential as an effective non-pharmacological option for managing dry eye in postmenopausal women. The trial was registered at Clinical Trials.gov (Identifier: NCT05964673)
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    Oral wound healing dilemma: recent treatment modalities using natural polysaccharide plant extracts and photobiomodulation
    (Springer International Publishing AG, 2026-02-03) Mostafa Ayman; Rania Momtaz; Radwa Hegazy; Sana Mostafa
    Purpose: Oral wound healing is a challenging process with high bacterial and viral load that impairs normal oral functions. The purpose of this narrative review is to investigate the recent treatment modalities of oral mucosal wound healing using the natural polysaccharide plant extracts (NPPE) and photobiomodulation (PBM) as well as the synergistic effect of both therapies. Methods: Specific keywords were applied to PubMed, Google Scholar, and Scopus databases. Twenty-four articles were selected after removing irrelevant studies including, fifteen studies investigating oral wound healing using NPPE, six using PBM, and three using PBM combined with NPPE. The included studies are ten in vitro studies, nine animal studies, and five clinical studies. Results: Results verified effectiveness of different NPPE, PBM and their combination in improving healing of oral wounds owing to its anti-inflammatory, antimicrobial, and antioxidant effects. When comparing individual modalities with combination therapy, the combined PBM and NPPE demonstrated better oral wound healing with superior pain relief, antioxidant, antimicrobial and anti-inflammatory effects, and less post-operative sensitivity. Conclusion: NPPE are considered as adjunct treatment to enhance oral wound healing. PBM is considered a quick and effective treatment when used with correct power and frequency. NPPE combined with PBM demonstrated promising results compared to individual modalities, however, available studies are limited. More research is needed to investigate precise cellular and molecular mechanisms underlying effective oral wound healing using combination therapy to pave the way for potential novel therapeutic applications.