MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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MSA Journals 138
A Full content for MSA university Faculties Journals
MSA University Academic Graduation Projects 1153
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MSA University Academic Research 3682
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RESEARCH & LANGUAGES CENTERS 18

Recent Submissions

Liver Enzymes in Non-Alcoholic Fatty Liver Diseases: Response to Pyramidal Versus Continuous Aerobic Training
(SINAPS LLC, 2025-12-20) Ali Mohamed Ali Ismail; Sallam Ali S. Sallam; Ibrahim Abdelrafea Salem; Asmaa M. Al-Emrany; Momen ELsaied ELsagher; Amira Hassan Abdelaziz; Ahmed Yasser Mostafa Marouf; Ramy Salama Draz
Purpose: The effect of choosing the type of exercise — the first-line conservative non-pharmacological therapy in managing non-alcoholic fatty liver disease (NAFLD) — on improving liver enzymes has not been fully investigated.: This was a comparative trial aimed to examine the response of liver enzymes to pyramidal progressive-intensity (interval) versus continuous moderate-intensity aerobic training in NAFLD women. Materials and Methods: Thirty-eight NAFLD women were randomized into a pyramidal training group (n=19) and a group of continuous moderate-intensity exercise (n=19). Both groups followed a reviewed 12-week low-calorie diet and received exercise training thrice weekly. Besides body mass index (BMI) and abdominal circumference (AC), NAFLD patients’ serum alanine transaminase enzyme (ALTE), alkaline phosphatase enzyme (ALPE), high-density lipoprotein (HDL), aspartate transaminase enzyme (ASTE), triglycerides (TGs), and gamma-glutamyl-transpeptidase enzyme (GGTE) were assessed before and after 12 weeks. Results: Significant improvements in all outcomes occurred after finishing both training forms. The pyramidal aerobic form produced more significant and pronounced improvements in the tested outcomes compared to the other form of exercise, moderate-intensity aerobic exercise. Conclusion: Both training forms, moderate-intensity aerobic exercise or pyramidal training, significantly improved NAFLD patients’ ALTE, BMI, ASTE, HDL, GGTE, AC, ALPE, and TGs, but the pyramidal form of exercise is more efficient than the continuous moderate-intensity form. © (2025), (SINAPS LLC). All rights reserved.
Evaluating responsive façade shading for enhancing daylighting performance in university classrooms across Egyptian regions
(Springer Nature, 2026-02-22) Manar Eltanbouly
Daylight quality and visual comfort are critical parameters in learning environments, particularly in climates with intense solar exposure. This study investigates responsive façade shading as a climate-adaptive strategy to improve indoor daylight performance in university classrooms across four Egyptian regions: West Cairo, Aswan, Alexandria, and Hurghada. A parametric simulation workflow was developed using Rhino, Grasshopper, Ladybug, Honeybee, Galapagos, and Wallacei-x to analyze annual daylight metrics (DA, UDI), visual comfort (DGP), and Quality of View (QV) under static and adaptive façade configurations. Findings demonstrate strong climatic dependence. Responsive shading consistently reduced over-lighting and lowered DGP, with the 50% opening ratio providing the most effective glare mitigation, while the 80% configuration improved daylight uniformity. Hurghada achieved the most balanced performance, combining stable DA and high QV with moderate glare levels. West Cairo maintained high DA but exhibited significant UDI instability, requiring finer modulation. Alexandria showed limited added benefit from responsiveness, and Aswan remained glare-dominated, indicating the need for additional control strategies. The study concludes that responsive shading should be deployed selectively and tailored to the climate, offering region-specific recommendations for future educational building design in Egypt.
Immuno-redox modulator loaded trehalosomal hydrogel for atopic dermatitis: formulation, optimization using D-optimal mixture design, in-vitro and in-vivo evaluation
(Elsevier B.V., 2026-03-19) Sara Sayed Hashem; Howida K. Ibrahim; Khaled Fathey EL Shaboury; Heba H. Awad; Riham A. El-Shiekh; Nihal Farid Younes
Gallic acid (GA) offers significant potential for managing atopic dermatitis (AD) owing to its potent antioxidant and anti-inflammatory properties; however, its hydrophilic nature (log P 0.7) severely limits skin permeation and localized bioavailability. To address this, the present study developed and optimized gallic acid-loaded trehalosomes using a D-optimal mixture design and a solvent-free fabrication method to enhance dermal retention and therapeutic outcomes. The optimized formulation (Opt-THL) was selected using a numerical desirability function (D = 0.835) that satisfied predefined constraints. Comprising phospholipid, trehalose, and Pluronic F127, it showed an entrapment efficiency of 72.4 ± 0.76%, particle size of 218.5 ± 0.70 nm, polydispersity index of 0.36 ± 0.001, and zeta potential of −32.2 ± 1.62 mV. It exhibited sustained release over 8 h, with release efficiency (RE%) of 56.81 ± 0.7% and mean dissolution time (MDT) of 1.87 ± 0.09 h. Integration of Opt-THL into a hydroxypropyl methylcellulose (HPMC) hydrogel (Opt-THL-Hgel) facilitated a biphasic release profile, effectively suppressing the initial burst and extending GA release for up to 24 h. Ex-vivo deposition studies revealed a significant 2.8-fold increase in skin retention compared to a conventional GA-hydrogel. In-vivo evaluation in a dinitrochlorobenzene-induced AD mouse model confirmed that Opt-THL-Hgel acts as a potent immuno-redox modulator, significantly reducing SCORAD indices and ear thickness, while restoring cutaneous antioxidant defenses (SOD, GPx, GSH) and downregulating pro-inflammatory cytokines (TNF-α, IL-6) compared with the AD model group (p < 0.05). These findings establish trehalosomes as a superior platform for the localized delivery of GA, offering a clinically relevant strategy for the long-term management of AD.
Comparative analysis of hybrid modelling for performance and emissions using biodiesel with nanoadditives and hydroxy
(Springer Netherlands, 2026-03-06) M. S. Gad; Ahmed Alenany; Ahmed M. Helmi
Fossil fuels provide the majority of the world’s energy needs. When fossil fuels are burned, harmful pollutants have negative impacts on the environment. It is advantageous to use biodiesel in diesel engines. Nanoadditives were employed to enhance the characteristics and usage of biodiesel in cold regions. Diesel was mixed with 20% WCO biodiesel. Distribution of cerium and titanium oxides in B20 was 25 and 50 parts per million. Using an alkaline electrolyser, water was electrolysed at a rate of 0.5 litre per minute to produce hydroxy gas. Influence of methyl ester blend containing hydroxy gas and nanomaterials on emissions and engine performance was investigated. The largest declines in specific fuel consumption were 15 and 20%, whereas cerium and titanium oxides at 50 ppm with hydroxy demonstrated increases in thermal efficiency of 14 and 19% when related to B20. When 50 ppm of cerium and titanium oxides with hydroxy were added, the biggest reductions in smoke were 15% and 21%, respectively, while the biggest decreases in NOx emissions were 24% and 35% for B20 + 50C + HHO and B20 + 50T + HHO, respectively. For titanium and cerium oxides with hydroxy, CO concentrations were reduced by 13% and 20%, respectively, whereas HC was declined by 25% and 36%. ANN and linear regression methods were utilised to model emissions and performance. For all variables, ANN and regression fared better, with R2 values above 0.97. For more ecologically friendly and effective engine operation, B20 with 50 ppm cerium and titanium oxides with hydroxy is advised.
Synthesis and biological evaluation of ibuprofen/o-vanillin Schiff base complexes with anti-inflammatory, anti-proliferative and anti-SARS-COV-19 activities
(Nature Research, 2026-03-07) Laila H. Abdel-Rahman; Doaa Abou El-ezz; Abdel-Mawgoud M. Abdel-Mawgoud; Mohamed R. Shehata; Mahmoud Abd El Aleem Ali Ali El-Remaily; Mohamed AbdelHameed; Shaaban K. Mohamed
This study presents the synthesis and comprehensive characterization of four novel metal-complexes formed from the reaction of copper(II), nickel(II), zinc(II), and vanadium(IV) salts with the bidentate ibuprofen Schiff base ligand (HL) in 1:1 metal-to-ligand ratio. The copper complex shows the highest antibacterial and cytotoxicity efficiency, in addition to a strong binding interactions with DNA. The in-vitro anti-inflammatory and anti-COVID-19 potencies of HL and its complexes were assessed, ranking them as: CuL > NiL > ZnL > VOL > HL.