MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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Recent Submissions

  • Item type: Item ,
    A Threshold Approach to Investigating Bitcoin's Environmental Impact
    (London Academy of Science and Business, 2026-03-31) Doaa Mohamed Salman; Salma Mahran; Islam Abdelbary
    The rapid growth of Bitcoin trading has created tension between financial innovation and environmental sustainability. While existing research has focused on mining energy consumption, the environmental consequences of trading activity – a primary economic driver – remain underexplored, particularly across different developmental contexts. This study examines whether Bitcoin trading volume affects progress toward Sustainable Development Goal 7 (SDG7), which mandates affordable and clean energy, and whether this relationship varies by developmental status and trading intensity. Utilising a balanced panel of 21 developed and developing countries from 2014 to 2023, we employ fixed-effects models, two-stage least squares instrumental variable regression, and threshold regression to analyse the relationship between Bitcoin trading activity and energy sustainability outcomes. The results reveal significant developmental asymmetry. In developing economies, high-volume Bitcoin trading regimes—exceeding a critical threshold of approximately $28.4 trillion in annual volume—are associated with a statistically significant deterioration in SDG7 progress (coefficient = -0.0153, p = 0.031). This effect operates through increased reliance on carbon-intensive electricity generation rather than aggregate energy consumption. No significant impact is observed in developed economies. The allocation of trading volume by exchange denomination may introduce measurement bias, and the analysis does not capture subnational variation in mining concentration. Subsequent studies should employ subnational data, extend analysis to other cryptocurrencies, and investigate which specific institutional characteristics most effectively mitigate environmental damage. Bitcoin's environmental impact is neither uniform nor linear but conditional on institutional context and trading intensity, underscoring the need for context-sensitive, volume-dependent regulatory interventions.
  • Item type: Item ,
    Assessment of cell viability of heat cured and 3D printed denture base resins on humans’ oral epithelial cells, and rats’ hepatic and myocardial cells
    (BioMed Central Ltd, 2026-07-15) Ahmed N. Elsherbini; Nancy N. Elsherbini; Tasneem M Soliman; Mona El-Deeb
    Objectives: Denture base materials contain unreacted monomers, which may act as bioactive compounds and affect cells and tissues in vital organs such as the liver and heart. The aim of this study was to assess the cytotoxic and cell viability effect of 3 Dimensional printed (3D) and heat cured acrylic (HCR) denture base resins on oral epithelial cells in humans and hepatic and myocardium cells in rats. Materials and methods: The Sulfo-rhodamine B (SRB) assay was used to evaluate cell viability. In 96-well plates, aliquots of 100 µL cell suspension (5 × 103cells) were incubated for 24 h. Another aliquot of 100 µL media containing denture base materials, acrylic resin (heat cured acrylic resin; Acrostone) and 3D printed resin (Denture bases; iFun) in different concentrations, 0.00(control), 0.01, 0.1, 1, 10, and 100 µg/ml were used to treat the cells of human oral epithelial cells, rats’ hepatic and myocardium cells. Results: There was a concentration dependent decrease in the cell viability of human oral epithelial cells, and rats’ hepatic and myocardium cells in both heat cured acrylic resin and 3D printed resin.100ug/ml concentration caused the highest decrease in cell viability percentage. However, there was a statistical significant difference between all concentrations in the 3 cell lines. Also, morphological picture showed the heat cured resin had a more deteriorating changes in the 3 cell lines more than 3D printed resin. Conclusion: 3D printed and heat cured acrylic denture base resins seemed to affect cell viability of human’s oral epithelial cells and rats’ hepatic and myocardium cells to some degree but without reaching cytotoxicity thresholds. Clinical relevance: Denture wearers wear their dentures for long period of time, and as dentures are made up of chemicals which may have a deteriorating effect on the patients’ general health. This research investigates which denture base material to be considered as the most biocompatible and safe for patients’ usage. Also, helps practitioners in choosing the more biocompatible material for their patients.
  • Item type: Item ,
    AI-Driven Teacher Preparation: A Constructivist and Cognitive Learning Perspective
    (AM Publications, 2026-07-11) Adel Mohammad Al-Zahrani; Ghada Abdelhady
    This paper explores the preparation of teachers through the lens of modern educational and learning theories, with particular attention to how artificial intelligence (AI) can augment educational planning and professional teacher development. Three major theoretical frameworks are examined: (1) Constructivist Theory, rooted in Piaget's cognitive development model, emphasizing the learner's active role in knowledge construction; (2) Meaningful Learning Theory (Ausubel), which underscores the critical link between new knowledge and pre-existing cognitive structures; and (3) Information Organization and Processing Theory, which explains how memory encoding and retrieval affect learning outcomes. The paper further integrates the McCarthy 4MAT model of learning styles to illustrate how AI-driven, learner centred strategies can be operationalized in contemporary teacher preparation programmers. Findings suggest that effective teacher preparation must transcend content delivery and focus on equipping teachers with adaptive, student-centred methodologies grounded in cognitive science.
  • Item type: Item ,
    Gamma Radiation–Induced Synthesis of Pectin/Arabic Gum‑Based Nanocomposite Hydrogels for Enhanced Water Remediation
    (Springer Nature, 2026-07-11) Asmaa Sayed; D. M. Aboelkhir; Razan Mohamed; Ayman Amin; Ghada A. Mahmoud
    Industrial dye contamination represents a major environmental concern, necessitating efficient and sustainable remediation strategies. In this study, a CuO@pectin/Arabic gum-g-diethylaminoethyl methacrylate (CuO@pectin/Arabic gum-g-DEAEMA) nanocomposite hydrogel was developed via gamma irradiation–induced copolymerization, providing a clean and initiator-free synthesis route. Successful incorporation of CuO nanoparticles was confirmed by DLS, EDX, and XRD analyses, while TGA demonstrated enhanced thermal stability. SEM observations revealed a rough and wrinkled surface morphology favorable for dye adsorption. BET analysis further showed that CuO incorporation increased the surface area from 14.05 to 28.22 m2 g⁻1 and the total pore volume from 0.08685 to 0.2201 cm3 g⁻1, confirming improved porosity and accessibility of adsorption sites. Adsorption studies showed that methylene blue (MB) removal follows a pseudo-second-order kinetic model, indicating chemisorption, while the Freundlich isotherm suggests heterogeneous multilayer adsorption. The CuO-containing hydrogel exhibited significantly improved adsorption performance compared with the pristine system. In addition, the nanocomposite demonstrated antibacterial activity against Gram-positive bacteria, indicating potential resistance to biofouling. The developed hydrogel combines green synthesis, enhanced porosity, improved adsorption efficiency, and multifunctional performance, making it a promising candidate for sustainable wastewater treatment applications.
  • Item type: Item ,
    TPGS-decorated lipopolymersomes encapsulating piperine for myocardial infarction: response surface optimization, in vivo Cardioprotection, and physiologically based pharmacokinetic modeling
    (Taylor and Francis Ltd., 2026-07-14) Marwa H. S. Dawoud; Heba T. Elbalkiny; Mai A. Zaafan; Nabila M. Sweed
    Piperine, derived from black pepper, exhibits powerful cardioprotective activity. However, its poor solubility limits its clinical translation for myocardial infarction (MI) management. This study aims to develop piperine-loaded lipopolymersomes for MI, to assess systemic and cardiac exposure. Lipopolymersomes were prepared using emulsification-solvent evaporation method, followed by surface coating with TPGS. The lipid-to-polymer ratio and nanoparticles-to-drug ratio were optimised for ideal particle size, zeta potential, and encapsulation efficiency. Oral pharmacokinetics and physiologically based pharmacokinetic (PBPK) modelling were conducted to evaluate bioavailability enhancement and predict cardiac exposure. Cardioprotective efficacy was assessed using an isoprenaline-induced mouse model of MI. TPGS-decorated lipoloymerosomes (O1-TPGS) exhibited a size of 188.56 ± 8.33 nm, a zeta potential of −19.67 ± 2.81 mV, and 98.67 ± 4.80%. entrapment efficiency. The formulation provided sustained piperine release over 72 h. Piperine oral systemic exposure was increased by 1.5-fold. PBPK simulation predicted a three-fold increase in cardiac concentration and area under the curve for O1-TPGS versus unformulated piperine. O1-TPGS normalised heart rate, reduced creatinine kinase-MB and troponin-I, and suppressed NLRP3, mTOR, NF-κB, and IL-6 than standard piperine, with superior preservation of myocardial architecture. TPGS-modified lipopolymersomes markedly enhanced the systemic and cardiac bioavailability of piperine, translating this pharmacokinetic improvement into superior cardioprotective effects in isoprenaline-induced MI.