MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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MSA Journals 138
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RESEARCH & LANGUAGES CENTERS 18

Recent Submissions

Molecular imprinted solid-phase extraction and analysis of Entecavir in presence of its induced degradation products and co-administered drug(s) in spiked human plasma, environmental three-color assessment and sustainability profiling
(Elsevier B.V., 2026-01-02) Sarah S. Saleh; Heba T. Elbalkiny
Entecavir (ETV) is an antiviral drug that acts by blocking the active viral replication process due to its chemical similarity to guanine. Through this study, the extraction of ETV samples was described, for the first time, using a synthesized molecular imprinted polymer solid phase extraction (MISPE). The MISPE was characterized using TEM and FTIR analysis. A green RP- HPLC method was developed for the quantitation of ETV using C18 column and a mobile phase consisting of 0.1 % phosphoric acid in water and methanol in a gradient mode delivered at a rate of 1 ml/min at room temperature. The UV detection was carried out at 245 nm. The analytical method was validated according to ICH guidelines with a linear range of (5-250 μg/mL). The specific extraction of ETV was carried out successfully using MISPE in presence of its induced acidic, and basic degradation products. MISPE was also used for the extraction of ETV from spiked human samples containing the co-administered drug lamivudine. The MISPE showed excellent selectivity, reusability and high recovery percentages (>90 %) when compared to Oasis HLB cartridges. The analytical procedure was compared to the reported methods in terms of environmental three-color assessment (ETCA): greenness (using AGREE, AGREEMIP and ComplexMoGAPI), blueness (using BAGI), and whiteness (using RGB-12 algorithms). The proposed method transcended in saving energy, efficiency and applicability. The sustainability profile for the proposed method was established using the efficient-valid-green (EVG) framework displayed via its radar chart, that showed balance between the three pillars, and the NQS index that displays the excellent alignment of the method with the UN-17 SDGs.
An in vitro evaluation of photothermal effect of gold nanoparticles on oral squamous cell carcinoma
(Elsevier Masson s.r.l., 2026-03-01) Sara Mohamed Ali; Mohamed Hossam Eldin Elmallahy; Amira Mohamed Gamal Eldeen; Seham Ahmed Abdel Ghani
Objectives: Oral squamous cell carcinoma (OSCC) is the leading type of cancer found in the head and neck area with a low survival rate. Gold nanoparticles (GNPs) show promise as an alternative cancer treatment due to their photothermal properties. The study investigated the in vitro effects of GNPs on oral cancer cells, focusing on their photothermal impact by analyzing the expression levels of Caspase-8, Cytochrome C, and C-Myc, both with and without laser application. Methods: The study included four groups: a control group with no treatment, and three treatment groups, doxorubicin (DOX), GNSCs, and GNSCs with laser exposure. Key parameters were measured, including the mode of cell death via fluorescence staining, Cytochrome-C and Caspase-8 expression using ELISA, and C-Myc oncogene expression through PCR. Results: The study found that GNSCs with laser exposure significantly increased apoptosis in oral cancer cells compared to GNSCs alone. DOX treatment reduced cell viability and increased apoptosis by elevating Cytochrome C and Caspase-8 expression. While GNSCs alone had no significant effect, combining GNSCs with laser exposure enhanced Caspase-8 levels. Both DOX and GNSCs with laser suppressed C-Myc expression, with DOX being more effective. Conclusion: Photothermal therapy using GNSCs combined with laser treatment shows promise as an alternative to chemotherapy and radiotherapy by inducing apoptosis through enhanced Caspase-8 activity and reduced C-Myc expression, although it is less effective than DOX in promoting Cytochrome C release and suppressing C-Myc.
FlashDetR: A deep learning pipeline for early detection and time estimation of flashover in high-voltage insulators using infrared videos
(Elsevier Ltd, 2026-01-04) Najmath Ottakath; Abdullah Lutfi; Ali Hamdi; Khaled Shaban; Ayman El-Hag
Flashover in high-voltage insulators poses a significant risk to power system reliability, potentially leading to outages and safety hazards. This study introduces an innovative deep learning-based approach for early prediction of flashover events and time-to-flashover estimation by analyzing infrared videos of dry band arcing, a known precursor to flashover. In this work, we propose a pipeline named Flashover Detector and Time Estimator , which integrates a transformer-based model to accurately predict flashover occurrences, while a Three Dimensional Convolutional Neural Network-based model estimates the time to flashover. Flashover Detector and Time Estimator progressively samples video frames at multiple scales, enhancing prediction accuracy. Experimental results demonstrate that the models achieve up to 88.73% accuracy in predicting flashover events and a mean absolute error of 3.41 in time-to-flashover estimation. These findings substantially improve the ability to implement preventive measures. Flashover Detector and Time Estimator thus represents a significant advancement in proactively managing power system reliability, with demonstrated effectiveness and real-time application potential.
Selenium and iron oxide nanoparticles mitigate doxorubicin-induced cardiomyopathy in rats via Nox1/p53 pathway inhibition
(Oxford University Press, 2025-09-11) Omnia F Hassan; Marwa H S Dawoud; Sherine M Ibrahim
Cardiovascular diseases, such as arrhythmia and cardiomyopathy, are leading causes of mortality worldwide. Cardiomyopathy is often triggered by oxidative stress. Objective The current study aims to investigate the therapeutic potential of selenium and iron oxide (FeO) nanoparticles, individually and in combination, in treating doxorubicin (DOX)-induced cardiomyopathy in rats. Method Cardiomyopathy was induced in Wistar rats, where selenium, FeO nanoparticles, or both were formulated and tested on the rat model. Key findings DOX administration revealed a significant elevation in cardiac enzymes: creatinine kinase (CK-MB) and troponin-1 (cTn-1), and elevation of oxidative stress markers, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and malondialdehyde (MDA), together with a reduction in superoxide dismutase (SOD) and glutathione peroxidase (GPx). A significant elevation in inflammatory markers, protein kinase C (PKC), nuclear factor-kappa B (NF-kB), and metalloproteinase-9 (MMP-9), was obvious after DOX administration in rats for induction of cardiomyopathy together with histopathological alterations. Selenium and FeO nanoparticles groups significantly improved oxidative stress, inflammation, and apoptosis compared with the DOX group. Combined selenium and FeO nanoparticle groups showed better results compared with the other treatment groups. Conclusion Selenium and FeO nanoparticles showed potential anti-oxidant, anti-inflammatory and anti-apoptotic effects in the treatment of DOX-induced cardiomyopathy in rats.
Improvements of gamma radiation-induced immunological, hematological, and some biochemical changes in male albino rats by custard apple (Annona squamosa) seed oil extract
(BioMed Central Ltd, 2025-12-01) Amina Aly; Wael El-Desouky; Mahmoud Mohammed; Mohamed AbdEl-Megid
Background: Annona squamosa seed oil extract (ASSOE) was used in the current study to investigate the radioprotective potential of ASSOE on radiation-induced hematological, immunological, and biochemical parameters in albino male rats. Materials and methods: The fatty acid profile of ASSOE was analyzed using GC. Total phenolic content (TPC) and total flavonoid content (TFC) were determined. Antioxidant activity for ASSOE was assayed by the DPPH activity assay, the anticancer activity was also valuated. Forty-nine male albino rats were separated into seven groups: group 1 (normal rats) were administered saline by gavage. Rats in the 2nd, 3rd , and 4th groups were subjected to a single dose of γ-radiation (4, 6, and 8 Gy), respectively, and then administered saline by gavage. The 5th, 6th, and 7th groups of rats were subjected to gamma radiation with 4, 6, and 8 Gy, respectively, then administered ASSOE by gavage (200 mg/kg B.W.) for 14 consecutive days. Results: Annona squamosa seed oil yield was 28.13%, which gave a TPC of 0.71 mg/g ASSOE, TFC of 0.145 mg/g ASSOE and DPPH percentage (65.41%). Fatty acids in ASSOE were oleic acid (57.80%), linoleic acid (23.31%), and palmitic acid (16.22%). The anticancer impact of ASSOE against Caco-2 and HepG-2 cell lines were, 47 ± 0.68 and 912.33 ± 10.81 µg/ml), respectively. Treated rats with ASSOE showed a noticeable increase in the percentage of immune cells, including CD4 and CD8. C-Reactive Protein (CRP) and Tumor Necrosis Factor-α (TNF-α) levels increased following γ-irradiation, but they dramatically dropped after 14 days of administration of ASSOE. Moreover, the 5th, 6th, and 7th groups exhibited notable improvements in all hematological parameters. After 14 days of treatment with ASSOE, cholesterol and triglyceride levels significantly decreased, reversing the rise that occurred following γ-irradiation. Conclusion: ASSOE is an excellent immunomodulator, radioprotector, and biochemical enhancer, suggesting that it might be used as an adjuvant during radiation therapy.