MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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RESEARCH & LANGUAGES CENTERS 18

Recent Submissions

Artifcial Intelligence-Guided Optimization of Hyaluronic Acid-Coated Liposomal Linagliptin for Targeted Management of Polycystic Ovary Syndrome
(Springer Science and Business Media Deutschland GmbH, 2026-04-02) Marwa H. S. Dawoud; Aml H. Zaghloul; Karen S. Zakhari; Mai I. Mahmoud; Zeinab M. Elnagdy; Nyera H. El‑Shafei; Mai A. Zaafan
Linagliptin, a DPP-4 inhibitor commonly used in the management of diabetes mellitus, has shown potential activity in polycystic ovary syndrome (PCOS). Linagliptin’s therapeutic effectiveness is limited by its poor membrane permeability and low oral bioavailability. This study aimed to formulate hyaluronic acid-coated liposomal linagliptin optimized through I-optimal design and AI-based entrapment efficiency (EE%) prediction. The effects of hyaluronic acid and drug concentrations on particle size (PS), polydispersity index (PDI), zeta potential (ZP), and EE% were systematically evaluated to develop an optimized delivery system for PCOS management. The optimized formulation (O1) demonstrated a PS of 152.5 nm, PDI of 0.373, ZP of –19.92 mV, and an EE% of 89.43%. The integrated AI-based predictive model achieved 89.8% accuracy, confirming its reliability for rational formulation design. In-vitro dissolution studies revealed a sustained drug release over 72 h from O1, in contrast to complete release within 3 h from unformulated linagliptin. In the PCOS-induced rat model, treatment with both unformulated linagliptin and O1 significantly improved insulin sensitivity and normalized lipid profiles. Notably, O1 markedly restored ovarian redox balance through modulation of the Keap1/Nrf2 pathway, indicating a mechanistic basis for the amelioration of PCOS-associated oxidative stress and metabolic dysfunction. Overall, the optimized HA-coated liposomal formulation demonstrated superior therapeutic efficacy and bioavailability compared to unformulated linagliptin, supporting its potential as a targeted repurposed nanocarrier-based therapy for PCOS management, where AI and response surface design are efficient tools for accelerating pharmaceutical formulation development and predicting formulation performance.
Alleviation of nonalcoholic steatohepatitis induced by tetracycline in rats by Coffee Arabica extract through autophagy signals (mTOR/LC3-B)
(Nature Research, 2026-03-27) Merehan Alaa-ElDin Mohamed; Said S. Moselhy; Shaimaa Rihan; Mustafa M. M. Elbakry
The autophagy mechanism is a key point for liver protection against nonalcoholic steatohepatitis (NASH). By specifically selecting Coffea arabica, this study leverages its high concentration of chlorogenic acid to modulate autophagy, a critical cellular recycling process that is typically suppressed during the development of NASH-related liver damage. We investigated the impact of Coffea Arabica methanolic extract (CAME) on autophagy-related markers (mTOR and LC3-B) mediated abrogation of tetracycline (TET) induced NASH in rats. Sixty male albino rats weighing 150 ± 10 g were equally divided into six groups: group 1 (control) received a chow diet; group 2 (NASH) received TET orally (1 g/kg bw) for 8 days; group 3 (CAME) received Coffea Arabica methanolic extract (CAME) orally (100 mg/kg bw) for 28 days; group 4 (treatment) received TET then CAME treatment for 28 days; group 5 (preventive) received CAME (100 mg/kg) for 28 days then TET orally (1 g/kg) for 8 days; and group 6 (protective) received both TET and CAME orally for 8 days. ELISA technique was used to measure mTOR and LC3-B content in liver tissue homogenate. Moreover, transmission electron microscope analysis carried out to detect pathological alterations in liver tissue. Also, molecular docking analysis was done. Coffea Arabica methanolic extract analysis by GC/MS revealed that CAME contained the highest percentage of chlorogenic acid (12.7963%). The biochemical data obtained pointed out that the mTOR level was significantly increased (~71.62%) while LC3-B decreased (~28.08%) in the NASH group compared with control. Administration of CAME abrogated these abnormalities. Liver examination by electron microscope indicated improvement abnormalities caused by TET in treatment with CAME. Docking study showed that chlorogenic acid has binding energy − 7.554 favorable to mTOR than ATP-γS. We concluded that CAME stimulated a protective mechanism against NASH via LC3B and mTOR modulation which should attract further research to confirm our results and fully understand its mechanism of induction.
Micro-shear bond strength of 3D printed hybrid ceramic with nonthermal plasma surface treatment: in-vitro study
(Nature Research, 2026-04-02) Mostafa El-Shazly; Ghada Alkaranfilly; Mahmoud Osama El-Ghazawy; Bassem Emad; Aliaa Mahrous
The optimal surface treatment for developing a durable bond of dual-cure self-adhesive resin cement and 3D printed hybrid ceramic has not yet been established. To evaluate the effect of Non-Thermal Atmospheric Plasma (NTAP), sandblasting (SB), and a combination of both techniques on Micro-Shear Bond Strength (µSBS) of dual-cure self-adhesive resin cement bonded to 3D printed hybrid ceramic after thermocycling, and assess the failure mode using SEM. A total of 75 resin tags of dual-cure self-adhesive resin cement (TheraCem) were cemented to fifteen discs of 3D Printed Hybrid Ceramic (Saremc- Print Crowntec) (five resin tags/ disc). Specimens were allocated into five groups according to discs’ surface treatment (n = 15); PL group: specimens were treated with NTAP, S50 group: specimens were treated with 50 μm AL2O3 SB, S110 group: treated with 110 μm AL2O3 SB, SP50 group: treated with 50 μm AL2O3 SB followed by NTAP, and SP110 group: treated with 110 μm AL2O3 SB followed by NTAP. Resin cylinders, 0.8 mm in diameter and 1 mm height, were cemented to discs. The µSBS test was performed using a universal testing machine after thermocycling. SEM was used to analyze the failure mode. Data were analyzed using Welch one-way ANOVA followed by the Games-Howell post hc test. A significant difference between groups (P = 0.026). The highest value was measured in SP50 (2.70 ± 0.49) (MPa), followed by SP110 (2.37±0.38) (MPa), then PL (2.35 ± 0.57) (MPa), and S110 (2.18 ± 0.31) (MPa), while the lowest value was found in S50 (2.12 ± 0.75) (MPa). Post hoc pairwise comparisons showed SP50 to have significantly higher values than S110 and S50 (P < 0.05). NTAP, particularly when combined with 50 μm sandblasting, improved µSBS to 3D-printed hybrid ceramics under the conditions of this in-vitro study. Clinical validation is recommended.
Plant-growth-promoting endophytic fungi of some wild plants from harsh habitats in Egypt
(Verlag Ferdinand Berger und Sohne GmbH, 2025-01-02) Ahmed M. Abdel-Azeem; Fatma A. Abo Nouh; Abdelghafar M. Abu-Elsaoud; Bassem A. Balbool
Fungal endophytes act as an immune system to the host plants, allowing them to tolerate biotic and abiotic stresses and promote plant growth. Fungal endophytes might be helpful for agricultural and horticultural applications. Fungal taxa that are recovered from wild plants growing in harsh environments, viz. North Sinai, is a sustainable source of novel bioactive metabolites. We isolated twenty-six endophytic fungal taxa from 6 wild plants (Cakile maritima, Datura metel, Hyoscyamus muticus, Artemisia monosperma, Zygophyllum album and Bassia indica). In the presented study we examined the frequent taxa for abiotic stress tolerance, e.g., salt and drought, the ability of plant growth promoting (PGP) traits production, e.g., Indole Acetic Acid (IAA), phosphate solubilization, ammonia production, and 1-aminocyclopropane-l-carboxylate deaminase (ACC), and the production of extracellular enzymes e.g., amylase, pectinase, chitinase, protease, cellulase, lipase, and urease. Most isolates showed variability in abiotic stress tolerance, production of plant growth promoting, and secretion of extracellular hydrolytic enzymes. Three isolates in this study showed the highest values in stress tolerance and plant growth promotion: Trichoderma atroviride (PP055997.1), Fusarium acutatum (PP038127.1), and Aspergillus terreus (PP038155.1).They were able to produce all the tested extracellular enzymes. According to the current in vitro research, studying fungal endophytes is a valuable strategy for creating systems that could shield various crop species that are vulnerable to drought and salt stress.
Synergetic effect of Camellia sinensis waste extract and zinc oxide nanoparticle for improving performance and appearance attributes of viscose fabrics
(Nature Research, 2026-03-27) Shahd Rasmy; Salwa Mowafi; Mahmoud Suleyman; Hosam El-Sayed
Eco-friendly textile dyeing technologies are increasingly popular because of raised environmental consciousness and the need for less polluting substitutes wefor synthetic dyes. Waste of black tea is an appropriate source of polyphenols and tannins with ecological as well as functional benefits, such as microbial resistance, and antioxidant activity. Herein, a new method for eco-friendlier dyeing and finishing of viscose fabric using black tea waste extract (BTWE) as a sustainable natural colorant for dyeing and functional finishing of viscose fabric was examined. The dyeing conditions, like pH, temperature, dye concentration, and time, were systematically regulated to assign the proper conditions for maximum color strength (K/S). The colorfastness of the dyed fabric against washing, perspiration, crocking, and light was determined. Using zinc oxide nanoparticles (ZnO-NPs) improved the performance of the dyed fabrics by making them more resistant to some pathogens. The results revealed that the optimum dyeing conditions were found to be pH 3, 45 °C, 4% dye, for 60 min. Finishing the dyed samples with ZnO-NPs enhanced the K/S and antimicrobial activity without negative impact on the mechanical strength. The dyed viscose fabric exhibited excellent resistance towards Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria as well as the fungus Candida albicans. The antioxidant activity of the dyed samples was greatly improved compared to undyed viscose fabric. However, enhancement of the ultraviolet protection factor of the dyed fabric was limited, likely due to inadequate surface coverage and lack of coating operations. The discrepancy in the chemical and morphological structures between the undyed and the corresponding dyed viscose fabrics was monitored using Fourier transform infrared spectroscopy and scanning electron microscopy, respectively. The correlation between the different dyeing parameters and the color strength as well as the colorimetric data was assigned using analysis of variance (ANOVA). The findings of this investigation justify the potential application of BTWE as a green colorant for one-pot sustainable dyeing and functional finishing of viscose fabrics.