MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

Communities in DSpace

Select a community to browse its collections.

Now showing 1 - 5 of 5

Recent Submissions

  • Thumbnail Image
    Item type: Item ,
    Dose-dependent effects of camel milk on immune function and metabolic health in weaning rats
    (Nature Research, 2026-02-05) Alyaa Farid; Mahy Mohamed; Maryam Amr; Gehan Safwat
    Breastfeeding cannot fulfill an infant’s nutritional needs beyond six months, necessitating theintroduction of alternative milk sources. Camel milk has emerged as a promising candidate due to itsrich profile of nutrients and immunomodulatory properties. This study evaluated the dose-dependenteffects of camel milk on general health and immune response in post-weaning rats, with particularattention to sex-specific differences. Male and female rats were divided into: control (GI), and fourtreatment groups receiving 2.4 mL (GII), 3.4 mL (GIII), 4.4 mL (GIV), or 5.4 mL (GV) of camel milkdaily for six weeks. Serum biochemical parameters, including lipid profile, liver and kidney functionmarkers, and immunological responses were assessed before and after immunization with sheep redblood cells. While higher doses (4.4–5.4 mL) significantly enhanced immune response and bone health,they concurrently elevated liver and kidney function parameters. The 3.4 mL dose balanced benefits,showing significant immune enhancement and bone health improvement without adverse metaboliceffects. These findings demonstrated that camel milk (3.4 mL for rats/473 mL for infants) safelyenhanced immune function, while higher doses risk metabolic stress. The results supported camelmilk’s potential as a nutritional supplement during weaning but emphasized the importance of dose regulation.
  • Thumbnail Image
    Item type: Item ,
    Therapeutic potential of mesenchymal stem cells in cisplatin-induced acute kidney injury via ASK-1/ TXNIP pathway modulation
    (Termedia Publishing House Ltd., 2025-01-04) Amal Abdelaziz; Radwa Y. Mekky; Omnia F. Hassan; Sherine M. Ibrahim
    Introduction: Acute kidney injury (AKI) is a diverse set of illnesses characterized by a rapid decline in kidney function. However, kidney transplantation and supportive therapies still have many limitations in slowing the progression of kidney diseases. The effective role of mesenchymal stem cells (MSCs) in cell-based therapy and endogenous repair for AKI is still under investigation. Several studies have indicated that MSCs could both repair and ameliorate kidney injury due to its anti-inflammatory and anti-apoptotic potential effects. The aim of this study was to evaluate the effects of MSCs on renal cell apoptosis in cisplatin-induced AKI rats and examine the underlying molecular mechanisms. Material and methods: Characteristics and homing of MSCs to kidney tissues were identified by flow cytometry and differentiation capability. After AKI induction by cisplatin injection in sixteen albino rats, the AKI rats were further subdivided into three subgroups. The first subgroup served as a positive control and the second one received 2 mg/kg furosemide (FUR), which served as a standard drug. The third subgroup received a single dose of 5 × 106 MSCs via tail vein injection once a week for 2 consecutive weeks. AKI-related biochemical parameters were assayed at 2 weeks after MSC treatment. Kidney histological changes were also evaluated. Moreover, apoptosis of kidney cells and expression of apoptosis-related proteins were assessed by western blot. Results: Compared with AKI rats, rats treated with MSCs showed suppressed serum levels of creatinine and blood urea nitrogen. MSC treatment alleviated the pathological abnormalities in the kidneys of AKI rats as shown by H&E staining. Furthermore, MSC treatment suppressed apoptosis of kidney cells in AKI rats via downregulation of apoptotic proteins: thioredoxin-interacting protein (TXNIP) and apoptosis signal-regulating kinase 1 (ASK1). Most importantly, MSC treatment promoted the expression of vascular endothelial growth factor (VEGF) in the kidneys of AKI rats. Conclusions: Our results suggest that MSCs could ameliorate renal injury of AKI rats via their anti-apoptotic properties. Also, the protective effects of MSCs may be mediated by their potential angiogenic effects.
  • Thumbnail Image
    Item type: Item ,
    A Low-Profile Fully-Fabric High Isolation Dual-Port MIMO Antenna For UWB Wearable Applications
    (Institute of Electrical and Electronics Engineers Inc, 2026-02-04) Mohamed El Atrash; Mennaalla S. Khalil; Waad A. Mahmoud; Mahmoud A. Addalla
    A compact, 2-port Multiple-Input-Multiple-Output (MIMO) antenna that is entirely made of textile is proposed for Ultra-Wide-Band (UWB) wearable applications. The conductive parts of the MIMO antenna are made of ShieldIt with a conductivity of 1.8 × 105 S/m and thickness of 0.17 mm. The MIMO antenna is mounted on a 1.5 mm thick Felt substrate. The designed MIMO antenna has a compact size of 30 mm × 45 mm and operates over the UWB frequency band ranging from 3.1 GHz to 10.6 GHz. It displayed an average radiation efficiency of 85.5% and a peak gain of 5 dBi within the UWB spectrum. To reduce the mutual coupling between the antenna elements, two approaches are applied. Orienting one radiator by 180° with respect to the other and adding a parasitic structure in-between the 2 radiators led to achieving a high isolation amongst the antennas. This is inspected through analyzing the achieved outcomes of S21 < −25 dB, very low Envelope Correlation Coefficient (ECC) < 0.001, high Diversity Gain (DG) > 9.995 dB, and low Channel Capacity Loss (CCL) < 0.2bits/s/Hz throughout the UWB spectrum. Furthermore, the Specific Absorption Rate (SAR) is lower than 1.6 W/kg, averaged over 1g of tissue, at various frequencies. Finally, the MIMO antenna was manually fabricated, where the tested outcomes matched with the simulated ones. Compared to the published work, the proposed antenna has a compact size, high radiation efficiency, has a bendable platform and achieves very competitive MIMO parameter. Therefore, the proposed MIMO antenna can be highly suggested for UWB wearable applications.
  • Thumbnail Image
    Item type: Item ,
    Development of coumarin-based acetylcholinesterase inhibitors: Synthesis, biological assessment and computational simulations
    (Academic Press Inc., 2026-01-05) Nouran E. Emam; Rana H. Refaey; Mohamed K. El-Ashrey; Walaa R. Mahmoud; Yassin M. Nissan; Emad M. Seif
    Novel coumarin-based derivatives ( 5 , 6a-c and 10a-j ) have been designed, synthesized and biologically assessed as multimodal anti-Alzheimer agents targeting acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and glycogen synthase kinase-3β (GSK-3β). The synthesized derivatives have been afforded in a good yield and the structures confirmed by the spectral analysis. Among these derivatives, four derivatives ( 10c , 10d , 10 f and 10i ) exhibited remarkable inhibitory activity against the acetylcholinesterase enzyme in nanomolar concentration (IC50 = 5.93 ± 0.06, 3.97 ± 0.15, 3 ± 0.1, and 4.97 ± 0.06 nM, respectively), surpassing the reference donepezil drug (IC50 = 7.03 ± 0.15 nM). Moreover, derivative 10 f demonstrated a significant BuChE inhibitory activity (IC50 = 303 ± 0.03 nM), about 2-fold the donepezil activity. Consequently, derivative 10 f was selected for the GSK-3β inhibition assay and displayed a greater inhibitory activity in nanomolar range (7.58 ± 0.83 nM) than the reference broad-spectrum kinase inhibitor staurosporine (8.63 ± 0.94 nM). Additionally, derivative 10 f was assayed for the iron chelating capacity and showed significant activity compared to the iron chelator EDTA. The molecular docking of derivatives 10c , 10d , 10 f , and 10i utilizing the AChE enzyme as a target protein (PDB: 4EY7 ) was evaluated and highlighted 10 f as a promising lead candidate with favorable interactions and high affinity. The key hydrogen bonds, hydrophobic contacts, and π–π stacking interactions support the observed bioactivity. Furthermore, molecular dynamics simulations indicated the stability of the compound–enzyme complexes, with low RMSD fluctuations and favorable binding free energies. Collectively, these findings emerge as derivative 10 f , a promising lead scaffold for Alzheimer's disease with multimodal activity.
  • Thumbnail Image
    Item type: Item ,
    Iron-based dendritic nanostructures incorporating curcumin and ibuprofen for possible multi-therapeutic applications
    (Elsevier Ltd, 2026-04-01) Richard Alkabalan; Ziad Mohamed; Doaa Abou El-ezz; Badriah Saad Al-Farhan; Laila H. Abdel-Rahman; Brian D. Wagner; Amani A. Abdelghani
    To create multifunctional dendritic nanostructures with antioxidant, antimicrobial, and anti-inflammatory properties, a total of nine dendrimers (D1–D9) were synthesized across three successive generations (G1–G3) with three different terminal groups: chloro, hydroxyl, and ibuprofen. Among these, the ibuprofen-terminated dendrimers across the three generations (G1-D3, G2-D6, and G3-D9) were selected for biological investigation owing to their potential therapeutic relevance. Structural confirmation was achieved for all dendrimers using 1H NMR and ATR-FTIR spectroscopy, while comprehensive physicochemical characterization was performed by SEM, CV, TGA, and fluorescence spectroscopy. SEM analysis revealed generation-dependent surface morphologies, ranging from amorphous-crystalline hybrids in G1-D3 to rough and highly crystalline domains in G3-D9, with G2-D6 exhibiting a uniform amorphous structure suitable for biological applications. TGA profiles indicated consistent three-step thermal degradation across generations, and CV demonstrated generation-dependent shifts in redox potential corresponding to the accumulation of redox-active cyclopentadienyliron centres. Among the synthesized dendrimers, the second-generation ibuprofen-functionalized dendrimer (G2-D6) emerged as the most promising therapeutic candidate. It exhibited superior DPPH radical scavenging activity (IC₅₀ = 16.25 μg/mL), surpassing free curcumin, ibuprofen, and the reference ascorbic acid, likely due to the combined effects of ibuprofen and organoiron moieties. G2-D6 also demonstrated potent antimicrobial and antifungal activity against E. coli, S. aureus, C. albicans, and A. niger, with antifungal performance against A. niger (inhibition zone: 37.0 ± 1.0 mm) exceeding that of Nystatin. Moreover, it achieved up to 96% inhibition in anti-denaturation assays, comparable to pure ibuprofen, highlighting its strong anti-inflammatory potential. These results position G2-D6 as a versatile, multifunctional nanotherapeutic with enhanced efficacy compared to its individual components and other dendrimer generations.